A device is provided for the stimulation of neurons that includes a non-invasive stimulation unit to generate stimuli in multiple stimulation channels, where the stimulation unit stimulates a neuron population in the brain and/or spinal cord of a patient in different locations for each of the stimulation channels. Moreover, the device includes a control unit that controls the stimulation unit to generate repetitive bursts in each of the stimulation channels, where each of the bursts includes multiple stimuli and is designed so that they do not reset the phase of the neuronal activity of the respective stimulated neurons.

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

This disclosure pertains to a system configured to control light exposure for circadian phase management and/or light deficient disorders of a subject. The system comprises a user interface, physiological sensors configured to generate output signals conveying physiological data of the subject, and a light control valve configured to block or reduce blue light ambient radiation reaching eyes of the subject. Processors are in communication with the user interface, the physiological sensors, the light control valve, and radiation generators. The processors cause the system to receive physiological goals of the subject, determine a light control plan based on the physiological goals, the physiological data, environmental data, and time data. The system operates the light control valve to block or reduce blue light ambient radiation based on the light control plan, and generate, using the one or more radiation generators, therapeutic light radiation based on the light control plan.

Systems and methods of the present disclosure are directed to neural stimulation via non-invasive sensory stimuli. The non-invasive sensory stimuli can reduce neuroinflammation, improving synaptic plasticity and stimulating neural networking, and improving microglial-mediated clearance of cerebral insults, which would otherwise contribute to the progression of brain atrophy, by inducing synchronized gamma oscillations in at least one region of a brain in a subject. Stimulations can adjust, control or otherwise manage the frequency of the neural oscillations to provide beneficial effects to one or more cognitive states or cognitive functions of the brain, while mitigating or preventing adverse consequences on a cognitive state or cognitive function that stem from progression of brain atrophy.

A system for therapeutic treatments with electromagnetic waves is described. The system comprises an antenna and an apparatus configured to generate a supply current for the antenna in order to generate the electromagnetic waves. The apparatus comprises a digital processing circuit configured to generate a first PWM signal, a switching stage configured to generate an amplified PWM signal, an analog low-pass or band-pass filter configured to generate the supply current by filtering the amplified PWM signal, and a current sensor configured to provide a digital sample indicative of the amplitude of the supply current.

Specifically, the digital processing circuit generates a sequence of first digital values of a periodic base pulse. Moreover, the digital processing circuit generates a second PWM signal having a packet switch-on period and a packet switch-off period, generates a third PWM signal having a train switch-on period and a train switch-off period, and generates an enable signal as a function of the second PWM signal and the third PWM signal. The digital processing circuit generates then a second digital value, wherein the second digital value is set to the first digital value when the enable signal has a first logic level and to zero when the enable signal has a second logic level.

In particular, the digital processing circuit generates the first PWM signal as a function of a third digital value indicative of the duty cycle of the first PWM signal, and varies the third digital value via a discrete proportional-integral regulation configured to regulate the difference between the second digital value and the digital sample to zero.

Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.

The present invention is directed to the use of gold nanoparticles to enable vision in the visually impaired. Retinal neurons remain functional despite photoreceptor degeneration. These neurons can be made light-sensitive to produce action potentials, by gold nanoparticles conjugated to high-avidity ligands for a variety of cellular targets. Once bound to a neuron, these particles transduce millisecond pulses of light into heat, which changes membrane capacitance, depolarizing the cell and eliciting action potentials. The technology described herein along with a camera and decoder can be used to aid the visually impaired by stimulating cells to send the appropriate messages to the visual cortex.

The present invention provides a myopia-preventing high intensity illumination apparatus for illuminating eyeballs and surrounding tissues via light that penetrating periorbital skin, subcutaneous tissue, then pass through cornea, iris, uvea, sclera and choroid, comprising a light source and a controller electrically connects to the light source, wherein the light source is projects to and illuminates on skin surrounding eyes, penetrates and enters subcutaneous tissue, iris, ciliary body and lens, as well as penetrates peripheral tissues of eyeballs, sclera, uvea, choroid and retinal pigment epithelium, and indirectly enters into vitreous and retina, so as to prevent myopia from further worsening by inducing microscopic biochemical reactions.

A device, for vision training and therapy, comprises a spectacle frame including a left rim, a right rim, and a bridge connecting the left rim and the right rim, wherein the left rim and the right rim include a plurality of therapeutic light sources located along the left rim and the right rim, for providing light therapy to the eyes of a user, a longitudinal member connected with the spectacle frame, and extending away from the spectacle frame, along the line of sight of the user, wherein the longitudinal member includes a plurality of colored light sources connected by a white stripe arranged to be viewable by both eyes of the user and a controller connected with the plurality of therapeutic light sources and the plurality of colored light sources. Further, the longitudinal member is extendible through an extension mechanism attached to the spectacle frame.

A relaxation mask includes: a main body that defines a pair of eye cavities; wiring; an earpiece that is coupled to the main body via the wiring; and a spring configured to bias the earpiece towards the main body.