A silicon carbide flow reactor fluidic module comprises a monolithic closed-porosity silicon carbide body, a tortuous fluid passage extending through the silicon carbide body, the tortuous fluid passage having an interior surface, and one or more thermal control fluid passages also extending through the silicon carbide body, the interior surface having a surface roughness of less than 10 μm Ra. A process for forming such modules is also disclosed.

A silicon carbide flow reactor fluidic module comprises a monolithic closed-porosity silicon carbide body and a tortuous fluid passage extending through the silicon carbide body, the tortuous fluid passage lying within two or more layers with the silicon carbide body, the tortuous passage having an interior surface, the interior surface having a surface roughness of less than 10 μm Ra. A method of forming the fluidic module is also disclosed.

A reactor system for thermally treating a hydrocarbon-containing stream includes a pressure containment vessel having an interior chamber defined by a first end, a second end, and at least one sidewall extending from the first end to the second end. A heat transfer medium converts electrical current to heat is positioned within the interior chamber of the pressure containment vessel, and the heat transfer medium has a first end face, a second end face, and channels extending between the first end face and the second end face. A heat sink reservoir includes molten salt, and at least one of a heater or heat exchanger is fluidly coupled to the heat transfer medium and thermally coupled to the heat sink reservoir.

One aspect of the present disclosure provides a system for producing 1,3-butadiene, which includes: a first supply unit, by which a first feed including a butene raw material, oxygen and steam is supplied; a second supply unit, by which a second feed including a butene raw material and oxygen is supplied; and a reaction unit, which includes a catalyst fixed bed and in which an oxidative dehydrogenation reaction takes place, wherein the first supply unit is connected to a front end of the reaction unit, and the second supply unit is connected to an intermediate end of the reaction unit.

The present invention provides a continuous upstream manufacturing process for the production of bispecific antibody products, which comprise at least two binding domains. The process comprises at least the steps of (i) providing in a perfusion bioreactor at least one mammalian cell culture, which is capable of expressing the bispecific antibody product, (ii) growing the mammalian cell culture at a first perfusion rate until a set point viable cell density is reached, and (iii) maintaining perfusion culture at a second perfusion rate, wherein the bispecific antibody product concentration in the bioreactor is kept below a threshold value. The bispecific antibody product is then subject to subsequent downstream processing. Moreover, the invention provides a bispecific antibody product produced by the continuous upstream manufacturing process.

The present invention relates to a reactor for producing synthesis gas which has a fluid-tight connection to a heat exchanger, and to a process for producing synthesis gas, preferably under high pressure, by using the reactor. The reactor comprises a mixer, a mixing space, a reactor space, separate inlets for at least two fluid reactants and an outlet for at least one fluid product, and a reactor shell surrounding these, and wherein the mixer comprises a mixer base, at least one mixer disk with channels for a first fluid, at least one mixer disk with channels for a second fluid, a mixer closure, and a mixer lid.

A device for the through-flow of a fluid may include a fluid inlet and a fluid outlet. A porous structure with interconnected pores is arranged between the fluid inlet and the fluid outlet, and the fluid inlet and the fluid outlet define an overall flow direction. The porous structure is coupled to a wall to provide for heat conduction between the porous structure and the wall. The porous structure has a porosity gradient along a first direction, which is cross to the overall flow direction. The porosity gradient develops along the first direction between a first porosity at a first location proximal to the wall and a second porosity larger than the first porosity at a second location remote from the wall. The difference between the second porosity and the first porosity may be at least 4%.

One aspect of the present disclosure provides a system for producing 1,3-butadiene, which includes: a first supply unit, by which a first feed including a butene raw material, oxygen and steam is supplied; a second supply unit, by which a second feed including a butene raw material and oxygen is supplied; and a reaction unit, which includes a catalyst fixed bed and in which an oxidative dehydrogenation reaction takes place, wherein the first supply unit is connected to a front end of the reaction unit, and the second supply unit is connected to an intermediate end of the reaction unit.

A device for the through-flow of a fluid may include a fluid inlet and a fluid outlet. A porous structure with interconnected pores is arranged between the fluid inlet and the fluid outlet, and the fluid inlet and the fluid outlet define an overall flow direction. The porous structure is coupled to a wall to provide for heat conduction between the porous structure and the wall. The porous structure has a porosity gradient along a first direction, which is cross to the overall flow direction. The porosity gradient develops along the first direction between a first porosity at a first location proximal to the wall and a second porosity larger than the first porosity at a second location remote from the wall. The difference between the second porosity and the first porosity may be at least 4%.

The invention relates to a regenerative reactor system which includes a reverse flow regenerative reactor. The reverse flow regenerative reactor includes a housing enclosing an interior region, and process flow components configured to manage the flow of a pyrolysis stream through the interior region. The process flow components include reactor beds. The reverse flow regenerative reactor also includes a pyrolysis inlet conduit for managing flow of the pyrolysis stream to the reverse flow regenerative reactor, and further includes a liquid distribution device that is configured to disperse a liquid portion of the pyrolysis stream along an internal surface of the pyrolysis inlet conduit.