Disclosed is a chemiluminescence measurement apparatus that includes: a support member configured to support a cartridge for measuring a test substance contained in a specimen by chemiluminescence measurement; a motor configured to rotate the support member so as to rotate the cartridge such that a process required for the chemiluminescence measurement proceeds in the cartridge; and a light receiver configured to receive light generated by chemiluminescence in the cartridge that is supported by the support member rotated by the motor. The cartridge supported by the support member and a light receiving surface of the light receiver are disposed inside a dark space surrounded by a light-shielding portion, and the motor is disposed outside the dark space.

This invention relates to methods, systems, and computer program products for verifying dispensing of a fluid from a pipette.

A pipetting device for outputting amounts of a dosing fluid of less than 1 μl including a fluid volume; a pipetting plunger that can be moved along a plunger path, wherein a displacement of the pipetting plunger brings about a first pressure change in the fluid volume; a movement drive which is force-transmittingly connected to the pipetting plunger in order to drive the pipetting plunger such that it moves along the plunger path; a sound source which is designed to generate at least one sound impulse as a second pressure change in the fluid volume; and a control device which is designed to control the movement drive and the sound source, the pipetting device having a pipetting channel which extends along a channel axis and in which both the pipetting plunger is moveably accommodated along the channel axis as the plunger path and the fluid volume is accommodated, wherein the fluid volume includes a working gas which wets a plunger surface of the pipetting plunger, wherein, in addition, the sound source is designed and arranged to generate the at least one sound impulse in the working gas.

A peristaltic pump-based apparatus for capturing circulating tumor cells (CTCs) from blood is provided that includes a feedback control architecture that uses models of pump operation and measures of internal pressure fluctuations of the pump (e.g., in the form time-varying and/or position-dependent pressure oscillation data) to adjust pump operating characteristics that smooth pump operation, thereby improving viscosity and consistency of fluid flowing through the pump to a connected microfluidic capture device.

A method is proposed for detecting an error state when aspirating a liquid, including: immersing a tip of an aspiration needle in the liquid, generating a negative pressure in the aspiration needle for a predefined time period to aspirate a predetermined partial volume of the liquid in the aspiration needle, continuously acquiring a sensor signal curve by means of continuous measurement of a sensor signal, which indicates a pressure in the aspiration needle, during an overall time period, which comprises the predetermined time period and furthermore a further time period following the predetermined time period, detecting the error state in the case that the sensor signal falls below a first threshold value during the predetermined time period, characterized by providing a reference signal curve, determining a deviation measure, which indicates a deviation of the sensor signal curve from the reference signal curve during the further time period, providing a predetermined second threshold value, detecting the error state as a function of the deviation measure and the second threshold value.

The present application relates to a pipetting device and a pipetting method for pipetting, therefore for aspirating and/or dispensing, a metered liquid using a working gas, independently of the flow- and/or wetting characteristics of the metered liquid, wherein a pipetting channel comprises a first working region, of which the known base temperature is in a lower base temperature range, and a second working region, of which the known working temperature is in a working temperature range that is increased with respect to the base temperature range.

Device for testing sealing of at least a part of a double-door sealed transfer system between two closed volumes, the system including a first flange and a and a second flange capable of being rigidly connected to one another, and a first door and a second door normally sealing openings respectively defined by the first and the second flanges, the device including a casing including a cavity provided with an opening, mechanical connection to a flange so that the cavity is closed by the flange and the door and an inflatable joint which, in the inflated state, is in contact with the flange and ensures a sealing allowing to verify the sealing between the flange and the door.

A pipetting apparatus and method for pulsed dispensing of small metered-liquid doses of no more than 1 μl. The apparatus includes a pipetting conduit at least partly filled with working gas, a pressure-modifying apparatus for modifying the pressure of the working gas, and a control apparatus for applying control to the pressure-modifying apparatus. The control apparatus can control the pressure-modifying apparatus so as to generate in the pipetting conduit, with respect to a reference holding pressure in the pipetting conduit which is necessary for immovable holding of the metered-liquid quantity, an overpressure pulse having a pulse duration of no more than 40 ms.

An automatic liquid transfer optimization pipetting apparatus and method is disclosed. Namely, a liquid handling apparatus includes a pump supplying a nozzle (i.e., a pipette tip) via a conduit, one or more pressure sensors, and an electronic controller, and wherein the pipette tip is submerged in a liquid. Further, a method of automatic liquid transfer optimization pipetting includes the steps of actuating the pump to move a designated volume of liquid and then allowing the system to settle to a steady state after completion of pump actuation.

A photometric dispensing nozzle unit, a photometric dispensing apparatus, and a photometric dispensing method are for preventing an increase in apparatus scale and have a simple structure to be easily handled. A nozzle performs suction/discharge of gas through a distal end opening and can have a dispensing tip attached thereto. A light guide end portion is provided in the nozzle and can receive or irradiate light at a distal end of the nozzle. A dispensing cylinder has a cylinder having a cavity therein, a plunger that is slidable in the cavity, and a suction/discharge port that performs suction/discharge of gas. A suction/discharge flow path passes through the nozzle and communicates with the suction/discharge port and the distal end opening of the nozzle. A light guide path is optically connected to the light guide end portion through the nozzle but not through the dispensing cylinder.