The compounds disclosed herein compound of Formula (I), substructures thereof, and pharmaceutically acceptable salts thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

##STR00001##

The compounds disclosed herein compound of Formula (I), substructures thereof, and pharmaceutically acceptable salts thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

##STR00001##

A surfactant of formula (I) ##STR00001## wherein each of R.sub.1 and R.sub.2 are independently a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, or an optionally substituted arylalkyl, R.sub.3 and R.sub.4 are independently an optionally substituted alkyl, an optionally substituted cycloalkyl, or an optionally substituted arylalkyl, x is an integer in a range of 2-8, y is an integer in a range of 1-15, z is an integer in a range of 4-10, n is an integer in a range of 2-5, and A is one of a carboxybetaine group, a sulfobetaine group, or a hydroxy sulfobetaine group. An oil and gas well servicing fluid containing the surfactant and methods of servicing an oil and gas well are also described.

A surfactant of formula (I) ##STR00001## wherein each of R.sub.1 and R.sub.2 are independently a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, or an optionally substituted arylalkyl, R.sub.3 and R.sub.4 are independently an optionally substituted alkyl, an optionally substituted cycloalkyl, or an optionally substituted arylalkyl, x is an integer in a range of 2-8, y is an integer in a range of 1-15, z is an integer in a range of 4-10, n is an integer in a range of 2-5, and A is one of a carboxybetaine group, a sulfobetaine group, or a hydroxy sulfobetaine group. An oil and gas well servicing fluid containing the surfactant and methods of servicing an oil and gas well are also described.

The present invention relates to amino alcohol compounds and to the preparation thereof from fatty esters comprising at least two carbon-carbon double bonds. In particular, the present invention relates to fatty amino alcohol compounds obtained by means of a process coupling, in a single step, a hydroaminomethylation reaction and a hydrohydroxymethylation reaction.

The present invention relates to amino alcohol compounds and to the preparation thereof from fatty esters comprising at least two carbon-carbon double bonds. In particular, the present invention relates to fatty amino alcohol compounds obtained by means of a process coupling, in a single step, a hydroaminomethylation reaction and a hydrohydroxymethylation reaction.

A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO by providing a composition comprising a compound set forth in Formula (I):

##STR00001##

Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.

Multifunctional crosslinkers are a reaction product between a polyaziridine compound and two or more functionalized benzophenones. The polyaziridine compound is linked to the functionalized benzophenones through two or more reacted aziridine groups. Coating compositions, comprising: a polymer, and multifunctional crosslinkers. Coated medical devices, comprise a lubricious coating bonded adjacent to an exterior surface of the medical device. The lubricious coating is prepared by UV-curing a coating composition, wherein the coating composition comprises: a water/isopropyl alcohol (IPA) soluble polymer and/or a UV-curable polymer, and a water/IPA soluble multifunctional crosslinker.

Multifunctional crosslinkers are a reaction product between a polyaziridine compound and two or more functionalized benzophenones. The polyaziridine compound is linked to the functionalized benzophenones through two or more reacted aziridine groups. Coating compositions, comprising: a polymer, and multifunctional crosslinkers. Coated medical devices, comprise a lubricious coating bonded adjacent to an exterior surface of the medical device. The lubricious coating is prepared by UV-curing a coating composition, wherein the coating composition comprises: a water/isopropyl alcohol (IPA) soluble polymer and/or a UV-curable polymer, and a water/IPA soluble multifunctional crosslinker.