Patent classifications
C07C309/61
PROCESS FOR THE PREPARATION OF POLYAMINOCARBOXYLIC ACIDS AND CHELATE COMPOUNDS THEREOF
The present invention relates to a process for the preparation of polyaminocarboxylic acids, in particular phenolic aryl- or alkyldiaminepolycarboxylic acids, preferably a compound of formula (I): wherein X is selected from the group consisting of: H, COOH, COO.sup.−Y.sup.+, OH, linear or branched C.sub.1-C.sub.5 alkyl, CH.sub.2OH, SO.sub.3H, SO.sub.3.sup.−Y.sup.+, wherein: —Y.sup.+ is independently selected from the group consisting of: Li.sup.+, Na.sup.+, K.sup.+, and NH.sub.4.sup.+; and wherein A is selected from: —A (CH.sub.2)n linear aliphatic system, wherein n=2, 3 or 4, preferably 2 or 3; and —an aromatic system of formula (II): wherein R1, R2 are independently selected from the group consisting of H, OH, and linear or branched C.sub.1-C.sub.5 alkyl; said process comprising the step of reacting, a phenol compound, glyoxylic acid and an aryl- or alkyldiamine in the presence of an iron source to obtain a reaction mixture comprising the compound of formula (I). The invention also relates to a process for the preparation of a chelate compound, which is a complex of the compound of formula (I) with iron.
PROCESS FOR THE PREPARATION OF POLYAMINOCARBOXYLIC ACIDS AND CHELATE COMPOUNDS THEREOF
The present invention relates to a process for the preparation of polyaminocarboxylic acids, in particular phenolic aryl- or alkyldiaminepolycarboxylic acids, preferably a compound of formula (I): wherein X is selected from the group consisting of: H, COOH, COO.sup.−Y.sup.+, OH, linear or branched C.sub.1-C.sub.5 alkyl, CH.sub.2OH, SO.sub.3H, SO.sub.3.sup.−Y.sup.+, wherein: —Y.sup.+ is independently selected from the group consisting of: Li.sup.+, Na.sup.+, K.sup.+, and NH.sub.4.sup.+; and wherein A is selected from: —A (CH.sub.2)n linear aliphatic system, wherein n=2, 3 or 4, preferably 2 or 3; and —an aromatic system of formula (II): wherein R1, R2 are independently selected from the group consisting of H, OH, and linear or branched C.sub.1-C.sub.5 alkyl; said process comprising the step of reacting, a phenol compound, glyoxylic acid and an aryl- or alkyldiamine in the presence of an iron source to obtain a reaction mixture comprising the compound of formula (I). The invention also relates to a process for the preparation of a chelate compound, which is a complex of the compound of formula (I) with iron.
Method for Preparation of Potassium 5-Iodo-2-Carboxybenzene Sulfonate
The invention discloses a method for the preparation of potassium 5-iodo-2-carboxybenzene sulfonate by diazotization of 5-amino-2-carboxybenzene sulfonate and subsequent reaction with KI.
Method for Preparation of Potassium 5-Iodo-2-Carboxybenzene Sulfonate
The invention discloses a method for the preparation of potassium 5-iodo-2-carboxybenzene sulfonate by diazotization of 5-amino-2-carboxybenzene sulfonate and subsequent reaction with KI.
Carbopyronone Compounds Useful as Diagnostic Adjuvants
Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.
Carbopyronone Compounds Useful as Diagnostic Adjuvants
Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.
ARAMID AMPHIPHILE SELF-ASSEMBLED NANOSTRUCTURES
Aramids and nanostructures formed from the aramids are described.
ARAMID AMPHIPHILE SELF-ASSEMBLED NANOSTRUCTURES
Aramids and nanostructures formed from the aramids are described.
Carbopyronone compounds useful as diagnostic adjuvants
Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.
Carbopyronone compounds useful as diagnostic adjuvants
Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.