There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula (II) as defined s herein with one or more suitable Vilsmeier reagent.

##STR00001##

There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula (II) as defined s herein with one or more suitable Vilsmeier reagent.

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Provided herein are methods for preparing ketone-containing organic molecules. The methods are based on novel iron/copper-mediated (“Fe/Cu-mediated”) coupling reactions. The Fe/Cu-mediated coupling reaction can be used in the preparation of complex molecules, such as halichondrins and analogs thereof. In particular, the Fe/Cu-mediated ketolization reactions described herein are useful in the preparation of intermediates en route to halichondrins. ##STR00001##

Provided herein are methods for preparing ketone-containing organic molecules. The methods are based on novel iron/copper-mediated (“Fe/Cu-mediated”) coupling reactions. The Fe/Cu-mediated coupling reaction can be used in the preparation of complex molecules, such as halichondrins and analogs thereof. In particular, the Fe/Cu-mediated ketolization reactions described herein are useful in the preparation of intermediates en route to halichondrins. ##STR00001##

A process is disclosed for producing renewable products, such as a renewable base oil, from a feedstock of biological origin. The process includes subjecting a feedstock containing free fatty acids and fatty acid glycerides, wherein at least one hydrocarbon chain is unsaturated, to esterification reaction in the presence of an alcohol. An ester stream thereby obtained is then subjected to metathesis conditions in the presence of a renewable alkene to obtain a metathesis product. Separation of the metathesis product includes recovery of a fraction containing or consisting essentially of C16 fatty acid esters, which is subjected to ketonisation reaction conditions to produce long chain ketones, which after hydrotreatment meet requirements for a renewable base oil. Ketonisation reaction produces renewable alkene usable in metathesis reaction.

A process is disclosed for producing renewable products, such as a renewable base oil, from a feedstock of biological origin. The process includes subjecting a feedstock containing free fatty acids and fatty acid glycerides, wherein at least one hydrocarbon chain is unsaturated, to esterification reaction in the presence of an alcohol. An ester stream thereby obtained is then subjected to metathesis conditions in the presence of a renewable alkene to obtain a metathesis product. Separation of the metathesis product includes recovery of a fraction containing or consisting essentially of C16 fatty acid esters, which is subjected to ketonisation reaction conditions to produce long chain ketones, which after hydrotreatment meet requirements for a renewable base oil. Ketonisation reaction produces renewable alkene usable in metathesis reaction.

The present invention reports the obtaining of carbonyl compounds and derivatives, through syntheses with high yield and purity, providing anti-humoral active principles with selective antiproliferative properties and anti-metastatic activity.

The present invention refers to the development of new polyfunctional push-pull butadienes and their O and C-prenylated, benzoylated and iodide derivatives, with high electronic conjugation in the lateral chain. These compounds exhibit high anti-tumor selectivity, causing cell death by apoptosis, also show anti-metastatic and non-mutagenic properties in the experimental studies performed.

The present invention reports the obtaining of carbonyl compounds and derivatives, through syntheses with high yield and purity, providing anti-humoral active principles with selective antiproliferative properties and anti-metastatic activity.

The present invention refers to the development of new polyfunctional push-pull butadienes and their O and C-prenylated, benzoylated and iodide derivatives, with high electronic conjugation in the lateral chain. These compounds exhibit high anti-tumor selectivity, causing cell death by apoptosis, also show anti-metastatic and non-mutagenic properties in the experimental studies performed.

##STR00001##

A method for preparing a compound of Formula (1) and compounds therefrom, comprising treating a compound of Formula (2) to provide a compound of Formula (5) and treating the compound of Formula (5) with a hydroxylamine salt wherein R.sup.1, R.sup.2 and m are as defined in the specification. The compound of Formula (1), prepared by the above method, can be used to prepare a compound of Formula (8) wherein R.sup.1, R.sup.2, R.sup.3 and m are as defined in the specification.

##STR00001##

A method for preparing a compound of Formula (1) and compounds therefrom, comprising treating a compound of Formula (2) to provide a compound of Formula (5) and treating the compound of Formula (5) with a hydroxylamine salt wherein R.sup.1, R.sup.2 and m are as defined in the specification. The compound of Formula (1), prepared by the above method, can be used to prepare a compound of Formula (8) wherein R.sup.1, R.sup.2, R.sup.3 and m are as defined in the specification.