The present disclosure provides a new procedure for preparing a key intermediate for active pharmaceutical ingredients useful in the treatment of diseases related to the central nervous system.

The present disclosure provides a new procedure for preparing a key intermediate for active pharmaceutical ingredients useful in the treatment of diseases related to the central nervous system.

A method for continuous synthesis of acylnaphthalene includes: mixing a raw solution containing 2-methylnaphthalene with an acylation liquid to obtain an acylation reaction liquid with a molar ratio of the 2-methylnaphthalene:the acylation agent:the Lewis catalyst of 1:1.3:1.5; adding the acylation reaction liquid into a microchannel reactor and a plurality of kettle reactors connected in series to perform acylation reaction, performing hydrolysis reaction on the acylation reaction liquid immediately after the acylation reaction liquid flows out of the plurality of kettle reactors to obtain a mixed solution, and subjecting the mixed solution to separation, rectification and crystallization, to obtain 2-methyl-6-propionylnaphthalene.

A method for continuous synthesis of acylnaphthalene includes: mixing a raw solution containing 2-methylnaphthalene with an acylation liquid to obtain an acylation reaction liquid with a molar ratio of the 2-methylnaphthalene:the acylation agent:the Lewis catalyst of 1:1.3:1.5; adding the acylation reaction liquid into a microchannel reactor and a plurality of kettle reactors connected in series to perform acylation reaction, performing hydrolysis reaction on the acylation reaction liquid immediately after the acylation reaction liquid flows out of the plurality of kettle reactors to obtain a mixed solution, and subjecting the mixed solution to separation, rectification and crystallization, to obtain 2-methyl-6-propionylnaphthalene.

A method for continuous synthesis of acylnaphthalene includes: mixing a raw solution containing 2-methylnaphthalene with an acylation liquid to obtain an acylation reaction liquid with a molar ratio of the 2-methylnaphthalene:the acylation agent:the Lewis catalyst of 1:1.3:1.5; adding the acylation reaction liquid into a microchannel reactor and a plurality of kettle reactors connected in series to perform acylation reaction, performing hydrolysis reaction on the acylation reaction liquid immediately after the acylation reaction liquid flows out of the plurality of kettle reactors to obtain a mixed solution, and subjecting the mixed solution to separation, rectification and crystallization, to obtain 2-methyl-6-propionylnaphthalene.

The invention relates to a new process for the manufacture of fluoroaryl compounds and derivatives thereof, in particular of fluorobenzenes and derivatives thereof, and especially wherein said manufacture relates to an environmentally friendly production of the said compounds. Thus, the present invention overcomes the disadvantages of the prior art processes, and in a surprisingly simple and beneficial manner, and as compared to the prior art processes, in particular, the invention provides a more efficient and energy saving processes, and also provides a more environmentally friendly process, for the manufacture of nuclear fluorinated aromatics, and preferably of nuclear fluorinated fluorobenzenes. Accordingly, in one aspect of the invention, an industrially beneficial process for preparing fluorobenzenes from halobenzene precursors using HF to form hydrogen halide is provided by the present invention. A beneficial and surprisingly simple use of chlorobenzene as an industrially interesting starting material in the manufacture of fluorobenzene is provided.

The invention relates to a new process for the manufacture of fluoroaryl compounds and derivatives thereof, in particular of fluorobenzenes and derivatives thereof, and especially wherein said manufacture relates to an environmentally friendly production of the said compounds. Thus, the present invention overcomes the disadvantages of the prior art processes, and in a surprisingly simple and beneficial manner, and as compared to the prior art processes, in particular, the invention provides a more efficient and energy saving processes, and also provides a more environmentally friendly process, for the manufacture of nuclear fluorinated aromatics, and preferably of nuclear fluorinated fluorobenzenes. Accordingly, in one aspect of the invention, an industrially beneficial process for preparing fluorobenzenes from halobenzene precursors using HF to form hydrogen halide is provided by the present invention. A beneficial and surprisingly simple use of chlorobenzene as an industrially interesting starting material in the manufacture of fluorobenzene is provided.

The invention relates to a new process for the manufacture of fluoroaryl compounds and derivatives thereof, in particular of fluorobenzenes and derivatives thereof, and especially wherein said manufacture relates to an environmentally friendly production of the said compounds. Thus, the present invention overcomes the disadvantages of the prior art processes, and in a surprisingly simple and beneficial manner, and as compared to the prior art processes, in particular, the invention provides a more efficient and energy saving processes, and also provides a more environmentally friendly process, for the manufacture of nuclear fluorinated aromatics, and preferably of nuclear fluorinated fluorobenzenes. Accordingly, in one aspect of the invention, an industrially beneficial process for preparing fluorobenzenes from halobenzene precursors using HF to form hydrogen halide is provided by the present invention. A beneficial and surprisingly simple use of chlorobenzene as an industrially interesting starting material in the manufacture of fluorobenzene is provided.

This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.