Provided is a method for producing a halogenated hydrocarbon magnesium compound, the method including bringing a halogenated hydrocarbon compound into contact with magnesium having a specific surface area of 1×10.sup.−5 to 2×10.sup.−4 m.sup.2/g. Also provided are methods for producing a tertiary alcohol compound and an organosilicon compound, wherein said production method is utilized.

The present invention provides methods for performing supercritical fluid chromatography comprising loading a sample to be separated by supercritical fluid chromatography onto a stationary phase comprising a spherical, monodisperse, core-shell particulate material comprising a nonporous core and one or more layers of a porous shell material surrounding the core, wherein the particles are sized less than 2 microns; and performing supercritical fluid chromatography to separate the sample.

The invention relates to a process for the production of sulfur containing silanes by the following steps (a) preparing an aqueous phase preparation by mixing sodium hydrosulfide or sodium sulfide, sulfur, Na2C03 and/or NaOH and a brine of step (f) and optionally of aqueous suspension of step (h), (b) adding 20 - 100 wt. -% of the total amount of phase transfer catalyst (c) continuously or in portions adding halogen alkyl silane, and simultaneously adding the rest of the total amount of phase transfer catalyst, in portions or continuously, (d) optionally adding brine from (f), optionally adding aqueous suspension from (h), optionally adding solid residue from step (k), separate the phase into a lower aqueous suspension and an upper organic phase and draw off the organic phase, (e) supply of the aqueous suspension from (d), optionally adding aqueous suspension from (h), separate in a salt cake and brine, (f) recycle all or a part of the brine of step (e) into step (a) and optional into step (d), (g) optionally distillate the rest of the brine from step (e) to yield aqueous distillate and aqueous suspension, (h) optionally recycle the aqueous suspension of step (g) into step (a) and /or (d) and/ or (e), (i) route the organic phase of step (d) to an evaporation step to yield a organic residue and low boiling distillate, (j) separate the organic residue from the evaporation step (i) into a sulfur containing silane and a solid residue, (k) optionally the solid residue of step (j) is recycled to step (d).

In an embodiment of the invention, a composition for treating a cell population comprises a medicant. The medicant moiety can be an illudofulvene analog. In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The affinity moiety can be an antibody, an antibody fragment, a receptor protein, a peptidic growth factor, an anti-angiogenic protein, a specific binding peptide, protease cleavable peptide, a glycopeptide, a peptide, a peptidic toxin, a protein toxin and an oligonucleotide. The affinity moiety can be covalently bound to the medicant via a linker.

The present invention relates to the field of chemical processes and, more particularly, it concerns valuable new chemical intermediates of formula (IV) for producing perfuming ingredients.

The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

The invention relates to a silane of the formula (1),

Si(R.sup.1).sub.m(R.sup.2).sub.n(R.sup.3).sub.4-(m+n)  (1)

as defined herein, where the silane has at least one group of the general formula (3):

##STR00001##

as defined herein, to a method for preparing the silane, and to curable compositions, containing the silane and at least one polyorganosiloxane.

The instant invention provides procatalysts and catalyst systems for olefin polymerization, olefin based polymers polymerized therewith, and process for producing the same. In one embodiment, the instant invention provides a procatalyst comprising a metal-ligand complex of formula (I):

##STR00001##

Novel processes are disclosed for the preparation of eribulin mesylate. Novel intermediate compounds used in the processes for making eribulin mesylate as well as processes for making the intermediates are disclosed.

The present invention relates to the technical field of medicines. Specifically disclosed is a compound as represented by formula I′, or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, symbols therein being as defined in the claims. The compound of the present invention may be used as a drug for regulating RET kinase activity or treating RET-related diseases, and has good pharmacokinetic properties.

##STR00001##