Embodiments described herein relate generally to compounds comprising allyl lactide residues. One aspect described herein relates generally to a compound or a pharmaceutically acceptable salt thereof, comprising allyl lactide residues and lactide residues, wherein the compound or pharmaceutically acceptable salt thereof is substantially free of valerolactone residues. Another aspect relates to a method of incorporating a drug into a compound, comprising: (i) providing a compound or a pharmaceutically acceptable salt thereof, comprising allyl lactide residues and lactide residues, wherein the compound or pharmaceutically acceptable salt thereof is substantially free of valerolactone residues; (ii) incubating the compound and a drug in the presence of a solvent for an incubation period to form a drug-loaded compound; and (iii) separating the drug-loaded compound from the solvent.

The invention relates to block copolymer comprising i) A first block wherein at least 65 mol-% of the repeating units of the first block are repeating units of the formula (I)—[CH.sub.2—CH.sub.2—O]—, ii) A second block wherein at least 90 mol-% of the repeating units of the second block are repeating units of at least one of formulae (II) or (III), wherein the groups R.sup.1, R.sup.2, and R.sup.3 independent of each occurrence are selected from hydrocarbyl groups having 1 to 40 carbon atoms, which are optionally substituted by ether or hydroxyl groups, and wherein the groups R.sup.1 and R.sup.2 are optionally linked to each other such that a nitrogen heterocyclic structure is present, iii) A third block which is different from the first block and the second block and which is more hydrophobic than the first block.

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An amphiphilic copolymer includes a first block, a second block and a linker covalently linking the first block with the second block, wherein the first block is a hydrophilic dendritic polyglycerol derivative having a polyglycerol backbone and carrying a plurality of sulfate or sulfonate residues substituting hydroxyl groups of the polyglycerol backbone, wherein the second block is a hydrophobic block comprising a polymer chosen from the group consisting of polycaprolactone, a polylactic acid polymer, and a copolymer of lactic acid and glycolic acid. The linker comprises a hydrocarbon having at least six consecutive methylene residues and a cleavable entity. The linker is devoid of a triazole-containing residue resulting from a reaction between an alkyne and an azide.

The present invention relates to a water-soluble co-polyester polymer. The polymer of the present invention is used for inline coating of BOPET film manufacturing, coating of BOPET film used as primer for vacuum metallization and surface coating of Aluminum sheets. The polymer of the present invention provides wide range of printability performances and high metal to film bond strength with minimum gain in weight. The disclosed polymer also provides Tape Test resistant printing and retort resistant layered/composite film.

Provided herein are methods and systems for producing biodegradable beta-propiolactone-based polyester polymers from renewable EO and CO on an industrial scale.

Provided are methods of producing sulfur- and phosphorus-containing polymers from beta-lactones. The sulfur- and phosphorus-containing polymers include bio-based sulfur- and phosphorus-containing polymers that may be obtained from renewable sources.

Polyester compositions are disclosed herein, as well as methods of making and using such polyesters. In some embodiments, the polyesters are formed from monomers derived from natural oils. In some embodiments, the polyesters are highly branched polymers, such as highly branched polymers that have low viscosity at higher molecular weights.

There are provided PVP-PLA block copolymers as defined in Formula (1): I wherein, x is an initiator alcohol having a boiling point greater than I 45° C., n is, on average, from 20 and 40, and m is, on average, from 10 and 40, wherein the block copolymers have a number average molecular weight (Mn) of at least 3000 Da. Polymers demonstrating flexibility in formulating multiple low solubility active pharmaceutical ingredients (APis) are described. Liquid and dry pharmaceutical formulations comprising an API are described, along with delivery methods, uses, and kits. APis may include, e.g. 11urbiprofon, celecoxib, acetaminophen, or propofol. Also provided is a method of synthesizing the PVP-PLA block copolymers by (i) initiating polymerization of D,L-Lactide from the initiator alcohol x to form poly(lactic acid), adding a xanthate to form a PLA macroinitiator, and polymerizing NVP onto the PLA macroinitiator, by controlled polymerization, to form the block copolymer compound of Formula (I).

An anti-tumor nano adjuvant is obtained by loading a drug on the vesicle formed by a reversibly cross-linked biodegradable polymer with an asymmetric membrane structure; the drug is an oligonucleotide activating an immune response; the vesicle formed by the degradable polymer is obtained by the self-assembly of a polymer followed by cross-linking; the molecular chain of the polymer includes a hydrophilic chain segment, a hydrophobic chain segment and positively charged molecules, successively connected; the hydrophobic chain segment is a polycarbonate chain segment and/or a polyester chain segment, which is compounded and loaded with a drug by electrostatic interaction; and the membrane is a polycarbonate chain segment and/or a polyester chain segment, which is reversibly cross-linked, biodegradable and has good biocompatibility, the dithiolane in the side chain thereof is similar to thioctic acid, a natural antioxidant in human body, and the shell thereof is based on PEG and targets cancer cells.

The invention generally relates to compositions comprising degradable polymers and methods of making degradable polymers. Specifically, the disclosed degradable polymers comprise a biodegradable polymer backbone, a nitric oxide linker moiety, and a nitric oxide molecule. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.