A fluorine-containing ether compound represented by the following formula (1) is provided.

R.sup.2—CH.sub.2—R.sup.1—CH.sub.2OCH.sub.2CH(OH)—(CH.sub.2).sub.n—CH(OH)CH.sub.2OCH.sub.2—R.sup.1—CH.sub.2—R.sup.2  (1)

(in the formula (1), n is an integer of 2 to 6, R.sup.1 is a perfluoropolyether chain, R.sup.2 is —OCH.sub.2CH(OH)CH.sub.2O(CH.sub.2).sub.mOH (m in the formula is an integer of 2 to 4)).

A polyalkylene ether glycol composition including a polyalkylene ether glycol including an alkoxy group serving as a terminal group. The polyalkylene ether glycol composition has a hydroxyl value of 220 or more and 750 or less. The ratio of the number of alkoxy group terminals of the polyalkylene ether glycol included in the polyalkylene ether glycol composition to the number of hydroxyl group terminals of polyalkylene ether glycols included in the polyalkylene ether glycol composition is 0.00001 or more and 0.0040 or less. Provided is a polyalkylene ether glycol composition having excellent compatibility with low-molecular-weight polyols, having suitable reactivity when used as a raw material for polyurethanes, and capable of achieving intended physical properties.

The curable composition is a curable composition containing an oxyalkylene polymer A having a reactive silicon group represented by —SiR.sub.a(X).sub.3-a, wherein the oxyalkylene polymer A has 6 or more terminal groups per molecule; the terminal group contains at least one selected from the group consisting of a reactive silicon group represented by —SiR.sub.a(X).sub.3-a, an active hydrogen-containing group, and an unsaturated group; the oxyalkylene polymer A has 0.3 or more reactive silicon groups per terminal group; and the number average molecular weight of the oxyalkylene polymer A is more than 25,000 and not more than 100,000.

The present disclosure relates to a novel material and composition to perform purification and concentration of biological sample or nucleic acid in single step. The present disclosure also relates to a method to use of the same in two phase system to purify and concentrate the target biological materials and/or nucleic acids with an improved detection accuracy for diagnostics performance.

A method of producing a polyoxyethylene derivative (1): ##STR00001##
where L1 is a divalent linker, X is a functional group capable of reacting with a physiologically active substance, a is 1 or 2, and n is from 11 to 3,650. The method includes Step (A): protecting 4 or 6 hydroxyl groups in a polyhydric alcohol having 5 or 7 hydroxyl groups by cyclic benzylidene acetalization to obtain a compound having a hydroxyl group at a 1-position and a protective group of a cyclic benzylidene acetal structure; Step (B): polymerizing from 11 to 3,650 moles of ethylene oxide to the compound obtained in the step (A) to obtain a polyoxyethylene derivative; Step (C): converting the hydroxyl group at a terminal of the polyoxyethylene derivative to a functional group capable of reacting with a physiologically active substance; and Step (D): deprotecting the protective group of the polyoxyethylene derivative.

The present invention relates to a Y-type discrete polyethylene glycol derivative as shown by Formula (I). The Y-type discrete polyethylene glycol derivative has the advantages of a determined molecular weight and number of segments in the chain, and can avoid the defects where the polyethylene glycol derivative itself is a mixture and the molecular weight is not homogeneous. The Y-type polyethylene glycol of the present invention can solve the problem of insufficient water solubility caused by an increase in the loading capacity when the discrete polyethylene glycol modifies an insoluble drug while increasing the drug loading capacity. ##STR00001##

The present invention relates to an improved method for preparing a high purity polyethylene glycol dialdehyde derivative. The preparation method can provide the polyethylene glycol dialdehyde derivative suitable as a raw material for pharmaceuticals because of high purity and terminal activity, by using PEG-diacetal, which is prepared by reacting polyethyleneglycol methanesulfonate with dialkoxy-1-propanol, as an intermediate.

Alkoxylated polycarboxylic acid esters are provided obtainable by first reacting an aromatic polycarboxylic acid containing at least three carboxylic acid units or anhydrides derived therefrom, preferably an aromatic polycarboxylic acid containing three or four carboxylic acid units or anhydrides derived therefrom, more preferably an aromatic polycarboxylic acid containing three carboxylic acid units or anhydrides derived therefrom, even more preferably trimellitic acid or trimellitic acid anhydride, most preferably trimellitic acid anhydride, with an alcohol alkoxylate and in a second step reacting the resulting product with an alcohol or a mixture of alcohols, preferably with an alcohol.

The present invention relates to a novel process for the synthesis of (per)fluoropolyether polymers and to certain novel (per)fluoropolyether polymers. The present invention also relates to the use the (per)fluoropolyether polymers thus obtained, as intermediate compounds for the manufacture of further polymers suitable for use as lubricants, notably for magnetic recording media (MRM).

The present invention relates to a novel process for the synthesis of (per)fluoropolyether polymers, to certain novel (per)fluoropolyether polymers. The present invention also relates to the use of the (per)fluoropolyether polymers thus obtained as intermediate compounds for the manufacture of further polymers suitable for use as lubricants, notably for magnetic recording media (MRM).