A manufacturing method of a sliding member for an artificial joint according to the present disclosure includes exposing a base member with ultraviolet rays in a state where the base member is in contact with an aqueous treatment solution containing a compound having 0.20 mol/L or more and less than 0.50 mol/L of phosphorylcholine group and a water-soluble inorganic salt.

The present invention generally relates to a method for applying a coating of hydrophilic polymers onto polyvinylalcohol-based hydrogel contact lenses to improve lubricity. In particular, the present invention is directed to a method for forming a coating on a contact lens, preferably a polyvinylalcohol-based hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user. The resultant polyvinylalcohol-based hydrogel contact lens has a coating with improved lubricity and good durability and also can be used directly from the lens package by a patient without washing and/or rinsing.

A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.

A hydrophilic copolymer that can form a surface lubricious layer exhibiting superior lubricating property and durability (lubrication retaining property), is provided. A hydrophilic copolymer having a good solvent solubility is provided. A hydrophilic copolymer is provided containing: structural units derived from a polymerizable monomer (A) having a sulfobetaine structure; structural units derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (—SO.sub.3H), a sulfuric acid group (—OSO.sub.3H), a sulfurous acid group (—OSO.sub.2H), and groups of salts thereof; and structural units derived from a polymerizable monomer (C) having a photoreactive group.

A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.

Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.

Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.

A hydrophilic copolymer that can form a surface lubricious layer exhibiting superior lubricating property and durability (lubrication retaining property), is provided. A hydrophilic copolymer having a good solvent solubility is provided. A hydrophilic copolymer is provided containing: structural units derived from a polymerizable monomer (A) having a sulfobetaine structure; structural units derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (SO.sub.3H), a sulfuric acid group (OSO.sub.3H), a sulfurous acid group (OSO.sub.2H), and groups of salts thereof; and structural units derived from a polymerizable monomer (C) having a photoreactive group.

The disclosure relates to a substrate comprising a surface at least part of which is coated with an epilamization agent, the epilamization agent including at least one compound in the form of a block copolymer comprising at least one block of M units linked by covalent bonds by their main chains, and at least one block of N units linked by covalent bonds by their main chains, the blocks being connected to each other by covalent bonds by their main chains in linear sequences, where M is a and N is ##STR00001##

A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.