Compositions and methods are provided comprising choline acetyltransferase (ChAT) and PEGylated ChAT for treating hypertension.

Provided are CD4+ T-cell-based compositions and methods for treating hypertension.

Expression systems for the expression of an 910 nicotinic acetylcholine receptor (nAChR) are described. Also described are methods of using the expression systems to identify agonists, antagonists, or allosteric modulators of an 910 nAChR.

Methods for the treatment of cancer that include the step of administering a viral vector carrying a nerve deleting, nerve ablating or nerve inhibiting payload, the administration leading to the deletion, ablation or inhibition of tumor-specific sympathetic nerves.

Provided are CD4+ T-cell-based compositions and methods for treating hypertension.

Compositions and methods are provided comprising choline acetyltransferase (ChAT) and PEGylated ChAT for treating hypertension.

Expression systems for the expression of an 910 nicotinic acetylcholine receptor (nAChR) are described. Also described are methods of using the expression systems to identify agonists, antagonists, or allosteric modulators of an 910 nAChR.

This invention provides for methods of treating one or more of endotoxemia, sepsis, colitis, elevated cytokine levels and an inflammatory condition in a subject in need thereof, which comprises administering an effective amount of a composition comprising purified choline acetyl transferase (ChAT) or purified ChAT conjugated to polyethylene glycol (PEGylated ChAT) and a pharmaceutically acceptable carrier to said subject.

Disclosed herein are isolated recombinant cells for the expression of 6 containing nicotinic acetylcholine receptors (nAChR) and methods of use thereof.

Disclosed herein are isolated recombinant cells for the expression of 64 nicotinic acetylcholine receptor (nAChR) and methods of use thereof.