Methods for the diagnosis and prognosis of neurodegenerative diseases, such as a Tauopathy or Alzheimer's disease, are described. Compositions and methods for the treatment of neurodegenerative diseases are also described.

Methods for the diagnosis and prognosis of neurodegenerative diseases, such as Alzheimer's disease, are described. Compositions and method for the treatment of neurodegenerative diseases are also described.

Methods for the diagnosis and prognosis of neurodegenerative diseases, such as a Tauopathy or Alzheimer's disease, are described. Compositions and methods for the treatment of neurodegenerative diseases are also described.

Methods and systems for synthesizing biological products within biomimetic condensates that enhance the concentration of enzymes, substrates, co-factors, and other molecules involved in the synthesis. The one or more enzymes involved in catalysis can be engineered to comprise low-complexity amino acid sequences or phase separation domains that can be controlled to drive reversible liquid-liquid phase separation, wherein the resulting biomimetic condensates comprise a traversable phase boundary between their dense internal portion and the less-crowded aqueous composition within which the condensates are maintained. Alternatively, biomimetic condensates can be first formed within the aqueous composition from affinity-tagged scaffold proteins that do not take part in catalysis, but are capable of recruiting into the condensate catalytic enzymes fused to an affinity tag partner. One or more enzymes can comprise or be recruited inside of the biomimetic condensate to generate a wide variety of desired chemical products.