Disclosed is a bi-directional exhalation valve useful for many applications such as in CPAP devices. The exhalation valve includes a valve body having a center chamber, side chambers, and bidirectional ports coupled to the center chamber via passages and a mechanism that provides fluid ingress into the bi-directional valve in a first mode of operation or fluid egress from the bi-directional valve in a second mode of operation. Unidirectional ports are coupled to the plurality of bidirectional ports to provide providing fluid egress from the valve in the second mode of operation, and a unidirectional port provides fluid ingress into the bi-directional valve in the first mode of operation. A mechanism including a center paddle, side paddles, and a shaft are arranged in an elongated compartment of the valve body, such that the shaft is pivots and the central and side paddles open and close corresponding ones of the input and output ports.

A particle manipulation system uses a MEMS-based, microfabricated particle manipulation device which has a sample inlet channel, output channels, and a movable member formed on a substrate. The device may be used to separate a target particle from non-target material in a sample stream. In order to improve the sorter speed, accuracy or yield, the particle manipulation system may also include a microfluidic structure which focuses the target particles in a particular portion of the sample inlet channel. This focusing element may include cavities of variable cross section along the channel length. In addition, a filtering element may also be included upstream of the focusing element.

Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.

A microchannel heat exchanger is configured for use as an evaporator in a fluid cooling system and includes an inlet header, an outlet header, and a plurality of microchannel tubes extending between and in fluid communication with the inlet header and the outlet header. A microvalve actuated hybrid spool valve is attached to and in fluid communication with the inlet header.

Disclosed is a bi-directional exhalation valve useful for many applications such as in CPAP devices. The exhalation valve includes a valve body having a center chamber, side chambers, and bidirectional ports coupled to the center chamber via passages and a mechanism that provides fluid ingress into the bi-directional valve in a first mode of operation or fluid egress from the bi-directional valve in a second mode of operation. Unidirectional ports are coupled to the plurality of bidirectional ports to provide providing fluid egress from the valve in the second mode of operation, and a unidirectional port provides fluid ingress into the bi-directional valve in the first mode of operation. A mechanism including a center paddle, side paddles, and a shaft are arranged in an elongated compartment of the valve body, such that the shaft is pivots and the central and side paddles open and close corresponding ones of the input and output ports.

Example devices include a fluidic device, such as a fluidic valve, including a body formed from a rigid body material including a fluidic source, a fluidic drain, and a fluidic gate, each of which may have a fluid connection with a chamber, or a portion thereof. The device may further include a gate transmission element, located within the chamber, that is controllable between at least a first position and a second position using a gate pressure received through the fluidic drain. Adjustment of the position of the gate transmission element may allow control of fluid flow through the device. Other devices, methods, systems, and computer-readable media are also disclosed.

Disclosed are techniques such as roll to roll processing to produce inlet valves for controlling entry of fluid into a compartment of a device. The valve includes a body having a compartment and an inlet into the compartment, with the inlet being bifurcated by a pair of spaced wall portions of the body that form a confining region and which pair of spaced wall portions together with wall portions of the body provide a pair of spaced inlet portions into the compartment and a valve member having a first portion that is position-able within a portion of the compartment, an intermediate portion, and a second portion coupled to the first portion by the intermediate portion, with the second portion position-able within the confining region and with the second portion having an obstruction portion.

Disclosed are examples of valve systems and methods of operating the respective valve systems. An example valve system may include a valve body, an inlet component, an outlet component and a valve tube. The valve body may include a first void and a second void. The inlet component may be coupled to the first void and the outlet component may be coupled to the second void. The valve tube may include a side port and may be positioned through the valve body and coupled to the first void, the inlet component, the second void, and the outlet component. Other valve system examples may include including a valve body, a first septum, a second septum, a first piston, a second piston and a tube. The disclosed methods describe the interaction of the respective components of the respective valve system example.

A system may include a first conduit configured to form a first batch of discrete volumes of aqueous fluid separated by spacing liquid disposed between consecutive volumes of aqueous fluid, the spacing liquid being immiscible with the aqueous fluid volumes; a second conduit, fluidically coupled to the first conduit, the second conduit configured to statically hold the first batch of discrete volumes of aqueous fluid; and a third conduit configured to receive the first batch of discrete volumes of aqueous fluid from the second conduit. The third conduit can be configured to transfer the discrete volumes of aqueous fluid of the first batch for downstream processing.

An evaporator assembly for an aerosol generating device is described. The evaporator assembly comprises a first body having a first plurality of through-channels, a second body having a second plurality of through-channels, wherein the first body and the second body are arranged such that the first and second plurality of through-channels overlap to allow the passage of a liquid from an inlet end to an outlet end of the evaporator assembly through the through-channels; and a heater arranged to heat the liquid as it passes through the through-channels, wherein the second body is moveable with respect to the first body such that the area of overlap is adjustable.