Provided is a device for electrical measurement designed to be able to perform high sensitivity detection by reading not only changes in steady-state current, but also the occurrence of transient current, and an electrical measurement apparatus including the device for electrical measurement. The device for electrical measurement includes a substrate on which are formed at least a sample separation channel and a sample migration channel, as well as a sample measuring unit, with one end of the sample separation channel formed to connect to one end of the sample migration channel, and the sample measuring unit including a first measuring unit connected to the sample migration channel, and a second measuring unit connected to the sample migration channel from the reverse side to the first measuring unit.

A device for counting particles comprises a detector arranged to produce an electrical measurement signal in response to the passage of one or more particles, and a comparator arranged to compare the measurement signal with a threshold signal and to increment a counting value when the measurement signal exceeds the threshold signal, characterized in that it furthermore comprises a threshold-adjusting circuit that applies a lowpass filter to the measurement signal, and that is connected to the comparator in order to use the resulting signal as threshold signal.

A particle detector for detecting nano-particles contained in fluid is provided. The particle detector includes a substrate and at least one pair of sensing electrodes disposed on the substrate. The substrate includes nano-pores, wherein the pore size of the nano-pores is greater than the particle size of the nano-particles, allowing the nano-particles contained in the fluid passing through the nano-pores. The at least one pair of sensing electrodes are positioned adjacent to at least one of the nano-pores.

A nanopore device measures a current signal Is that flows through the nanopore device, which has an aperture and an electrode pair. A transimpedance amplifier converts the current signal Is into a voltage signal Vs. A voltage source is configured to apply a DC bias voltage Vb across the electrode pair in a normal measurement mode, and to apply a calibration voltage Vcal across the electrode pair in a calibration mode. In the calibration mode, at least one circuit constant of a measurement apparatus is calibrated based on the output signal Vs of the transimpedance amplifier and the calibration voltage Vcal.

Disclosed is a particle-measuring device, including: a measurement part including first and second electrodes and measuring a mass of particles with a change in signals transmitted and received between the first and second electrodes, wherein the first and second electrodes are patterned on a base made of a piezoelectric material and transmit/receive signals to/from each other; and an adsorption part provided in an adsorption region between the first and second electrodes and configured to adsorb fine particles according to a temperature change. According to such a configuration, the particle-measuring device does not interfere with the resonance rate of a piezoelectric material while having a high adsorption rate, thereby providing excellent particle measurement quality.

An air particle detecting device includes a main body, a processor received in the main body, and an air particle counter received in the main body. The air particle counter is electrically coupled to the processor. The air particle counter is configured to calculate data related to a quantity of particulate matter and transmit the data to the processor. The processor is configured to calculate a concentration of PM 2.5 according to the data.

A system and method for generating a signal map are disclosed. The system includes memory, one or more processors, instructions stored in the memory and configured for execution by the one or more processors. The system generates a signal profile for each block of a plurality of blocks obtained from a tissue sample, where each block of the plurality of blocks contains multiple cells. The system generates a spatial map of signals from a plurality of signal profiles corresponding to the plurality of blocks. In some embodiments, the system further creates a tree of cell populations from the spatial map. In some embodiments, the system includes a microfluidic device (e.g., a microfluidic sensor chip) configured to detect impedance of cells, and the signal profile for each block is an impedance profile generated based on impedances detected from the microfluidic device.

A pore chip includes a membrane having a pore. With the diameter of the pore as d and the thickness of the membrane as t, the relation 1?t/d<2 is satisfied.

An optics-free method for single cell profiling, particularly white blood cells such as neutrophils is disclosed. Embodiments relate to multi-parametric biophysical profiling of neutrophils using a microfluidic impedance-deformability cytometry device. The device comprises a first flow channel comprising a particle focusing region, a detection region comprising a first pair of electrodes, a cell deformation zone and a second pair of electrodes. A multi-frequency impedance response of each cell before and after deformation is measured respectively by the first and second pairs of electrodes, such as to quantify membrane opacity, nucleus opacity, cell size and deformability index. A second flow channel bifurcated into two split flow pathways that converge in an intersecting manner with the first flow channel forms a cross-junction in a cell deformation zone, to hydrodynamically deform each cell by perfusing a sheath fluid along the two split flow paths from two opposite sides of the sample flow channel.

The present disclosure relates to a sensor arrangement (1) for analyzing substances in a material, comprising a substrate (2), a first reception area (5) for receiving a first material, an electronic component sensor (3), a test area (4) that is in contact with the electronic component sensor (3), and a control device (10). The first reception area (5) and the test area (4) are arranged on the substrate (2). The control device (10) is configured for controlling the first reception area (5) and/or the test area (4) to move a portion of the first material from the first reception area (5) into the test area (4). Further, the present disclosure relates to a method for operating such a sensor arrangement (1).