Devices and methods for controlling the properties of chemical species during time-dependent processes. A device includes a reactor for containing one or more chemical species of a time-dependent process, an extraction pump for automatically and continuously extracting an amount of the one or more chemical species from the reactor, one or more detectors for measuring property changes of the one or more extracted chemical species and generating a continuous stream of data related to the one or more property changes to the one or more chemical species during a time interval, and a process controller configured to fit the continuous stream of data to a mathematical function to predict one or more properties of the one or more chemical species at a future time point and make one or more process decisions based on the prediction of one or more properties at the future time point.

Disclosed is a method for classifying monitoring results from an analytical sensor system (20), by allowing (100) a first set of analyte sample solutions to interact with a ligand (3) and acquiring (101) a set of response data, extracting (102) at least one interaction parameter from the response data, and for each analyte sample solution providing (103) a trained machine learning algorithm with the interaction parameter(s). The trained machine learning algorithm classifies (104) each analyte sample solution based on the interaction parameter(s) into at least one quality classification group indicative of the interaction of the analyte sample solution with the ligand (3). The machine learning algorithm is trained (200) using a set of interaction parameters extracted from response data obtained from interactions between a second set of analyte sample solutions with at least one ligand (3), and at least one quality classification group indicative of the interaction of the analyte sample solution with the ligand (3).

There is provided a method of detecting a change of a state of a liquid comprising the steps of: •providing a liquid detection medium (12) comprising a liquid and having a plurality of anisotropic magnetic particles suspended therein; •applying a modulated magnetic field across at least a portion of the liquid detection medium (12), wherein the magnetic field induces an alignment of the magnetic particles; •introducing electromagnetic radiation (22) into the liquid detection medium (12); •detecting a variable which is modulated by the applied magnetic field, wherein the variable is associated with the interaction of the electromagnetic radiation (22) with the magnetic particles and wherein the change in the state of the liquid causes a variation in the detected variable; and •correlating the variation in the detected variable with the change in the state of the liquid.

The present invention is enclosed in the area of machine learning, in particular machine learning for the analysis of High or Super-resolution spectroscopic data, which typically comprises analysis of highly complex samples/mixtures of substances and/or data with low resolution, for instance Laser-Induced Breakdown Spectroscopy (LIBS). It is an object of the present invention a method of computational self-learning for characterization of one or more constituents in a sample, from electromagnetic spectral information of such sample, which changes the paradigm associated with prior art methods, by using only sub-optical spectral information, i.e., obtaining the resolution of the spectral information and thereby be able to extract spectral lines—thus determining a spectral line position—from such spectral information, hence avoiding all the uncertainty associated with pixel based methods. It is also an object of the present invention a computational apparatus configured to implement such method.

The present disclosure is to provide a measurement chip, a measuring device, and a measuring method which can accurately estimate an analyte concentration with a simple configuration. A measurement chip may include a propagation layer, an introductory part, a drawn-out part and a reaction part. Through the propagation layer, light may propagate. The introductory part may introduce the light into the propagation layer. The drawn-out part may draw the light from the propagation layer. The reaction part may have, in a surface of the propagation layer where a reactant that reacts to a substance to be detected is formed, an area where a content of the reactant changes monotonously in a perpendicular direction perpendicular to a propagating direction of the light, over a given length in the propagating direction.

The disclosure directed to methods for measuring an analyte alone or in combination with total protein in biological samples. More particularly, the disclosure relates to methods for measuring an analyte and/or total protein using one or more colorimetric reagents alone or in combination with protein precipitation reagents.

The present invention relates to provide, among other things, the methods, devices, and systems that can simply and quickly collecting and analyzing a tiny amount of vapor condensates (e.g. exhaled breath condensate (EBC)).

A system includes a dip tube, a feed line, and a check valve. The dip tube is inserted through an opening in a source of chemical precursor and into the chemical precursor in the source. A portion of the feed line is located in the dip tube. The feed line passes out of the dip tube. The chemical precursor is capable of flowing out of the source through the feed line in a downstream direction. The check valve is located in the portion of the feed line in the dip tube. The check valve permits the chemical precursor to pass substantially only in the downstream direction. The feed line is coupled to a transfer pump that draws the chemical precursor out of the source through the portion of the feed line in the dip tube.

The invention pertains to a device for determination of a catalyst state in a chemical reactor and to a method for detecting a catalyst state under in situ reaction conditions. A reactor is provided with a solid catalyst provided in a reactor chamber. A fluid sample is taken from the reactor chamber and is transferred to a sample chamber. The temperature at the extraction site of the sample in the reactor chamber is determined and the temperature of the sample chamber is adjusted to the same temperature. A small amount of the catalyst provided in reactor chamber is provided in sample chamber and is contacted with the sample flow. Spectroscopic information is then obtained on the catalyst provided in sample cell, e.g. by an IR spectrometer.

An automatic analysis apparatus comprises: a light source generating light having a center wavelength equal to or shorter than 340 nm; a fluorescent substance excited by the light source light, and generates light together with transmitted light from the light source, having a wavelength of 340 nm to 800 nm; a condenser lens; at least one slit; a reaction cell holding a reaction solution where a specimen and reagent are mixed, and that the light source light and the light from the fluorescent substance enter; and a detector that detects light transmitted through the reaction cell. The light source, fluorescent substance, condenser lens, and slit are provided along a straight light corresponding to the optical axis. The width of the slit's opening is equal to or narrower than the width of a ray forming an image of the light source at the position of the slit.