Disclosed is an optical flow cell (100, 300) and a method (400) for bioprocessing applications. The optical flow cell (100, 300) comprises a fluid inlet (102, 302), a fluid outlet (104, 304), and a fluid flow channel (106, 306) provided between said fluid inlet (102, 302) and said fluid outlet (104, 304). The optical flow cell (100, 300) also comprises an output optical waveguide (108, 308) configured to emit light into said fluid flow channel (106, 306), and a collector optical waveguide (110, 310) configured to collect light from said fluid flow channel (106, 306). An optical pathlength adjuster (120, 320) for varying the optical pathlength (130, 330) between said output optical waveguide (108, 308) and said collector optical waveguide (110, 310) is also provided.

Systems are provided for a modular multi-wavelength UV-VIS detector unit, such as an absorbance detector (e.g., spectrophotometer) included in a high-performance liquid chromatography system. In one example, a detector unit includes one or more light emitters and a sliding assembly configured to slidingly move a flow cell relative to the one or more light emitters, the one or more light emitters mounted on a floating rig to facilitate alignment between the one or more light emitters and the flow cell when the sliding assembly is in a closed position.

An apparatus for analysing a liquid sample comprising particles, comprises: a first chamber (12) and a second chamber (14), and an optical path between the first chamber (12) and the second chamber (14), wherein: the first chamber (12) is a sample chamber comprising: a sample space for receiving the sample; a light input (24) for input of light into the first chamber (12) for interaction with the sample; and an exit aperture (26) arranged for scattered and/or reflected light to pass from the first chamber via the optical path to the second chamber (14); the second chamber (14) is a detection chamber comprising: an input aperture (28) for receiving light from the optical path; and a detector (25) for detecting, or a detector aperture for receiving, light to be detected; wherein the first chamber (12) and the second chamber (14) provide at least one light integrating volume, and wherein the first chamber (12) is configured such that in operation the liquid sample is present in the first chamber (12) and isolated from the second chamber (14).

An optical measurement unit for a scanning device, a scanning device, and a method for operating a scanning device, for high throughput sample analysis of biological samples are disclosed. An illumination system is used to emit light of at least two different illumination wavelength ranges, and an imaging system is used to detect light of at least two different detection wavelength ranges, in order to detect electromagnetic radiation within a field of view for determining the positioning of a sample within the field of view.

Disclosed herein are integrated photonics systems (3800) for biosensing including an interrogator photonic circuit (3802) and cartridge (3804) and methods using these systems. The cartridge (3804) comprises a sensor photonic integrated subcircuit. The cartridge (3804) is configured to receive a biological sample. The interrogator photonic circuit (3802) is optically coupled to the cartridge (3804) an comprises: (i) a light source (3806) configured to generate light; and (ii) one or more waveguides configured to carry the light, wherein the light is used to determine a characteristic of the biological sample in the cartridge (3804). A system can have an assembly of a plurality of modular photonic integrated subcircuits. Each subcircuit can be pre-fabricated and can be configured to transfer light to and receive light from another subcircuit based on the first functionality. An output port of a first subset of the subcircuits can be configured to be aligned with an input port of a second subset of the subcircuits. At least one subcircuit can be configured to be removed from the first integrated photonics assembly and connected to a second integrated photonics assembly having a second functionality. The first integrated photonics assembly can be different from the second integrated photonics assembly and the first functionality can be different from the second functionality.

An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.

Analyte collection and testing systems and methods, and more particularly to disposable oral fluid collection and testing systems and methods. Described herein are methods and apparatuses to achieve significant improvements in the detection of fluorescence signals in the reader.

In a sample analyzing apparatus, an injector assembly injects a reagent onto a sample, and luminescent light from the sample is transmitted to a detector. The assembly may be movable toward and away from the sample. The assembly may include one or more needles that communicate with one or more reservoirs supplying reagent or other liquids. The assembly may include a light guide for communicating with the detector. A cartridge may be provided in which the assembly, one or more reservoirs, and one or more pumps are disposed. The cartridge and/or the apparatus may be configured for enabling rinsing or priming to be done outside the apparatus. The cartridge and/or the apparatus may include one or more types of sensors configured for detecting, for example, the presence of liquid or bubbles in one or more locations of the apparatus and/or the cartridge.

Systems for collecting light (e.g., in a flow stream) are described. Light collection systems according to embodiments include: a mount having an orifice for receiving light, an adapter configured for attaching a camera to the mount and a fastener for attaching a lens to the distal end of the mount and a releasably attachable connecter that is configured for coupling to an orifice plate and an aligner that is configured to couple with an aligner on the mount and maintain optical alignment between the mount and connector. Methods for coupling a connector and a mount are also described. Systems and methods for measuring light emitted by a sample (e.g., in a flow stream) are also provided.

In one aspect of the present disclosure an optical measurement device includes a sample holder defining a sample plane, wherein the sample holder is configured to arrange a sample carrier including an array of measurement positions in the sample plane, an illumination unit configured to illuminate the sample plane, a detector and an optical imaging system configured to image the sample plane including the array of measurement positions onto the detector, the optical imaging system including two or more curved reflective elements adapted to image the sample plane onto the detector with a magnification of between 2:1 and 1:2 and the detector being configured to take an image of all measurement positions of the array of measurement positions at a time.