A bubble measurement system includes a bubble detector including a vessel having a flow path configured to receive a flow of fluid including air bubbles from a bubble generator and an imaging system. The imaging system includes an imaging device for imaging the fluid and air bubbles in the flow path of the vessel of the bubble detector. The imaging system has an imaging controller coupled to the imaging device and receiving images from the imaging device. The imaging controller processes the images to measure bubble size of each air bubble passing through the bubble detector. The imaging controller includes a pairing module comparing successive images and the air bubbles in successive images to measure all bubbles flowing through the vessel.

A component measurement apparatus includes: a chip insertion space for inserting a component measurement chip provided with a reagent that reacts with a component to be measured in a sample; a light emitting unit configured to emit radiation light to the component measurement chip in a state in which the component measurement chip is inserted into the chip insertion space; a light receiving unit configured to receive light transmitted through or reflected from the component measurement chip; and a control unit configured to determine whether there is a possibility that an incorrect processing mode has been selected for execution.

This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.

This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.

A device may determine a calibration value for a spectrometer using light from a first light source; deactivate the first light source after determining the calibration value; perform measurement with regard to a sample based on the calibration value, wherein the measurement of the sample is performed using light from a second light source; determine that the calibration value is to be updated; and update the calibration value using the light from the first light source.

The present disclosure includes systems and methods for calibration of an optical sensor package, including setting an initial detection threshold of a detector, gradually increasing a power level of a signal generator that is in communication with a detector to cause a detected power at the detector to exceed the initial detection threshold, storing in a memory a first power level of the signal generator at which the detected power at the detector exceeds the initial detection threshold, and adjusting the initial detection threshold of the detector to an adjusted detection threshold to include a detection buffer amount within the adjusted detection threshold.

A method for measuring optical signal detector performance that includes directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector. A first characteristic of light detected by a first sensor of the first optical signal detector is measured while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector. Light emitted from the optical signal detector is directed into a first void in the first detection zone of the optical signal detector. A second characteristic of light detected by the first sensor of the optical signal detector is measured while the first void is in the first detection zone of the optical signal detector. And an operational performance status of the optical signal detector is determined based on at least one of the first characteristic and the second characteristic.

By irradiating a sensor chip including an analyte labeled with a fluorescent substance with excitation light from an excitation light irradiation unit for emitting the excitation light using a specimen detector including the excitation light irradiation unit and a fluorescence detection unit for detecting fluorescence, fluorescence emitted from the fluorescent substance is detected by the fluorescence detection unit. When the analyte is detected on the basis of a detection value depending on the intensity of the detected fluorescence, a corrected detection value is calculated by correcting the detection value using individual difference information acquired in advance on the basis of an individual difference between the specimen detectors and a correction coefficient for each sensor chip.

A method for measuring optical signal detector performance that includes directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector. A first characteristic of light detected by a first sensor of the first optical signal detector is measured while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector. Light emitted from the optical signal detector is directed into a first void in the first detection zone of the optical signal detector. A second characteristic of light detected by the first sensor of the optical signal detector is measured while the first void is in the first detection zone of the optical signal detector. And an operational performance status of the optical signal detector is determined based on at least one of the first characteristic and the second characteristic.

Systems and methods here may be used for automated alignment and focus adjustment for one or multiple sample gemstones on a stage, including determining gemstone sample tilt based on image data, automatically moving a stage to align the tilted sample, determining a focal plane that overlaps a focal point of a camera with the gemstone, and automatically moving a stage to the focal plane.