Disclosed sensors can include at least one resonator (in some embodiments, at least two resonators) and various other structures that may be formed in association with the resonators. The at least one resonator in embodiments can include a bottom electrode, a piezoelectric layer, and a top electrode, wherein the piezoelectric layer is positioned between the bottom electrode and the top electrode.

The copolymer of the present disclosure comprises a first structural unit represented by Formula (1) and a second structural unit represented by Formula (2). In Formula (1), R.sup.1 is a hydrogen atom or a methyl group. R.sup.2 and R.sup.3 are each independently a hydrogen atom or an alkyl group having from 1 to 4 carbons. x1 is an integer of 1 to 4.

In Formula (2), R.sup.4 is a hydrogen atom or a methyl group. R.sup.5 and R.sup.6 are each independently a hydrogen atom or an alkyl group having from 1 to 4 carbons. x2 is an integer of 1 to 4, and y is an integer of 3 to 7.

Disclosed sensors can include at least one resonator (in some embodiments, at least two resonators) and various other structures that may be formed in association with the resonators. The at least one resonator in embodiments can include a bottom electrode, a piezoelectric layer, and a top electrode, wherein the piezoelectric layer is positioned between the bottom electrode and the top electrode.

A method of manufacturing a biosensor having a microbeam linked to a support, at least one electrode a biological molecule A grafted onto the microbeam in a different zone from the zone where the electrode is embedded, and a mechanoelectrical transducer for converting variations of the mechanical properties of the microbeam into an electrical signal, when the biological molecule A is placed in contact with a biological molecule B to be detected and/or quantified. The method includes: formation of an electrode on fluoropolymer material sheet, passivation of the electrode(s), creation of the form of the biosensor in the sheet of polymer material and separation of this form from the sheet, functionalization either of a prefunctionalized zone or of a zone of the microbeam, this zone being different from the zone wherein the electrode is embedded, and grafting of a biological molecule A onto the functionalized zone.

Disclosed sensors can include at least one resonator (in some embodiments, at least two resonators) and various other structures that may be formed in association with the resonators. The at least one resonator in embodiments can include a bottom electrode, a piezoelectric layer, and a top electrode, wherein the piezoelectric layer is positioned between the bottom electrode and the top electrode.

The invention provides a chemical detection system for detecting at least one target chemical species, including a self-sensed cantilevered probe array having a plurality of self-sensed cantilevered probes, at least one chemical-sensitive coating material applied to at least one cantilevered probe in the cantilevered probe array, and an interface circuit that is coupled to the cantilevered probe array. At least one cantilevered probe in the cantilevered probe array exhibits a shifted cantilevered probe response when the cantilevered probe array is exposed to the target chemical species and the interface circuit actuates the cantilevered probe. A handheld chemical detection system and a method of operation are also disclosed.

A method of manipulating and/or investigating cellular bodies (9) is provided. The method comprises the steps of: providing a sample holder (3) comprising a holding space (5) for holding a fluid medium (11); providing a sample (7) comprising one or more cellular bodies (9) in a fluid medium (11) in the holding space (5); generating an acoustic wave in the holding space exerting a force (F) on the sample (7) in the holding space (5). The method further comprises providing the holding space (5) with a functionalised wall surface portion (17) to be contacted by the sample (7) and the sample (7) is in contact with the functionalised wall surface portion (17) during at least part of the step of application of the acoustic wave. A system and a sample holder (3) are also provided.

The present invention provides a method for analyzing a liquid sample that solves a problem of a kinetically slow equilibrium at a liquid-solid interface, the problem occurring when liquid sample analysis is performed with a chemical sensor. In the method for analyzing a liquid sample according to an embodiment of the present invention, a component to be analyzed in a liquid sample is adsorbed on a receptor layer of a chemical sensor, one or more kinds of gases are then supplied to the chemical sensor, and a response thereof is measured. As a result, since a slow equilibrium at a liquid-solid interface is not used, a high-sensitivity measurement can be performed in a short time, and existing findings regarding analysis of gas samples on which much progress in research has been achieved can be used.

A method comprises providing a sample holder having a holding space for a sample comprising particle(s) in a fluid medium, the holder comprising a wall providing a wall surface portion, and providing a signal generator for generating an acoustic wave in the holder; providing using the signal generator a driving signal to the holder generating a standing longitudinal acoustic wave in the holder comprising at least one of a node and an antinode; and determining an acoustic resonance frequency characteristic. The method further comprises: providing a sample comprising particle(s) in a fluid medium in contact with the wall surface portion; determining a variation in the resonance frequency characteristic of the holder; determining a difference in position of one or more of the particles with respect to a node and/or an antinode of the acoustic wave and/or the wall surface portion, in particular contact, attachment and/or adhesion.

A polymer material is contained in a sensing film of a sensor element having a quartz plate, an electrode made of a metal film provided on the quartz plate, and a sensing film provided on the electrode, and has a structural unit that contains one or more ethylene unsaturated bonds and is originated from a compound containing one or more functional groups reactive to a gas.