A distributor element comprising: at least two fractal plates each defining a level below an adjacent fractal plate, an uppermost fractal plate comprising a first number of first openings, each of the first openings surrounded at a lower side by one of a plurality of first walls and, in the first level between the first walls, one or more first hollow spaces defining one or more first fluid paths, a second fractal plate comprising a second number of second openings, each of the second openings surrounded at a lower side by one of a plurality of second walls and, in the second level between the second walls, one or more second hollow spaces defining one or more second fluid paths, the second number being higher than the first number, and each of the first fluid paths and each of the second fluid paths having substantially a same length.

A chromatography device (201; 201′) comprising: – at least one chromatography material unit (203), wherein said chromatography material unit comprises a convection-based chromatography material and is of a substantially rectangular shape having a length (L) and a width (W); - at least one fluid distribution system (207) which is configured to distribute fluid into and out from the at least one chromatography material unit (203), wherein said fluid distribution system (207) comprises a distribution device (209a) and a collection device (209b) between which said chromatography material unit (203) is sandwiched, wherein said distribution device (209a) and said collection device (209b) each comprises a number of parallel grooves (255) for distribution and collection respectively of a fluid to be passed through the chromatography material unit (203), wherein said parallel grooves are reaching over substantially the whole length (L) of the chromatography material unit (203) and are distributed over substantially the whole width (W) of the chromatography material unit (203).

A flow cell for a liquid chromatography detector comprises a substrate formed of a glass material; a fluidic channel extending through the substrate; and at least one gas filled region formed in the substrate along at least a portion of a length of the fluidic channel. A portion of the glass material separates the fluidic channel and the gas filled region. An interface between the gas filled region and the portion of the glass material separating the fluidic channel and the gas filled region enables total internal reflection of light propagating along the fluidic channel.

A liquid chromatography column, utilizing horizontal or radial flow of sample material passing there through, includes a housing defining a chamber therein, at least one removable screw lid, and first and second longitudinally extending porous frits positioned within the chamber. A bed or packing of particulate, chromatographic separation material is positioned within the chamber and intermediate the porous frits, the first of the porous frits being adjacent the housing and an inlet channel, the second of the porous frits being positioned adjacent a core member and an outlet channel. A distributor is operatively connected to the inlet channel, and a collector is connected to the outlet channel. The distributor and the inlet channel are constructed to direct associated material to be separated in the bed evenly across a longitudinal length of the bed in a horizontal direction.

A chemical reactor is implemented on a substrate and has an inlet for receiving a fluid and/or a gas; a filter element for reducing or preventing that materials cause a blockage in the fluid supplied and/or the gas supplied in a part of the chemical reactor located further away; and a part located further away for transporting and/or processing the fluid and/or the gas. The part located further away has a depth dlow smaller than the depth dhigh of the inlet. The filter element has a first duct part and a second duct part; the first duct part is positioned closer up against the inlet than the second duct part, the first duct part is deeper than the second duct part, the first duct part has a diverging width and is free from pillar structures, and the second duct part is filled with filter pillars.

Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration. Alternatively, the agitator in the lowered position permits the chromatography resin packing material to operate in a mixed, slurry configuration.

A chemical reactor is implemented on a substrate. The chemical reactor has multiple ducts for transporting a fluid and/or gas during use of the chemical reactor, in which the ducts optionally include pillar structures and at least one connection duct connected between two of the multiple ducts for transporting the fluid and/or gas from one duct to another. In the connection duct, a series of individual pillar structures are positioned behind each other in the longitudinal direction of the connection duct.

A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.

A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.

A distributor is described for distributing a fluid flow from a smaller to a more broad fluid flow. It comprises a fluid input and a plurality of fluid outputs, and a channel structure in between the fluid input and the plurality of fluid outputs. The channel structure comprises alternatingly bifurcating channel substructures and common channel substructures wherein the substructures are arranged so that fluid exiting different channels from a bifurcating channel substructure mixes in a subsequent common channel substructure, and whereby fluid channels of the bifurcating channel substructure are arranged such that these do not contact the subsequent common channel substructure at the edges thereof.