Methods for estimating the solvency potential for various chemical additives used for asphaltene deposit remediation or inhibition have been developed. These methods can be used for remediating or inhibiting asphaltene deposition in various applications including upstream production (e.g., near-wellbore, downhole, flow-lines, separators), midstream processes (e.g., pipe lines, transport, and storage), and downstream (e.g., hydrocarbon refining).

The disclosure provides methods, including automated methods, to detect levels of polyanions such as polyvinyl sulfonates in fluids such as buffers by complexometric or titration-based techniques. Such polyanionic compounds have been shown to inhibit enzymes involved in PCR that confounds efforts to monitor the purity of proteins obtained from cell culture, such as biologies and biosimilars.

Methods for estimating the solvency potential for various chemical additives used for asphaltene deposit remediation or inhibition have been developed. These methods can be used for remediating or inhibiting asphaltene deposition in various applications including upstream production (e.g., near-wellbore, downhole, flow-lines, separators), midstream processes (e.g., pipe lines, transport, and storage), and downstream (e.g., hydrocarbon refining).