An HF coil assembly for generating independent alternating magnetic fields in an examination volume of a magnetic resonance apparatus is presented, the HF coil assembly comprising a first coil pair of saddle coils and a second coil pair of saddle coils, each saddle coil having longitudinal conductor elements and curved conductor elements arranged along a common lateral surface of a circular cylinder having a cylinder axis. Each coil pair comprises curved conductor elements and longitudinal conductor elements which are interconnected at a high frequency. The saddle coils also have diagonal conductor elements and/or bridge elements that connect the longitudinal and curved conductor elements. The coil pairs are opposite to each other relative to the cylinder axis.

The present disclosure provides medical devices having MRI-compatible circuitry. Preferably, the devices do not project an enlarged profile, yet their position can be determined during an iMRI procedure. Illustrative embodiments of such a device can include a base surface, a first conducting layer disposed on the base surface, a first insulating layer disposed over at least a portion of the first conducting layer, and a second conducting layer disposed over at least a portion of the first insulating layer.

This disclosure generally relates to stable water isotope labeling followed by detection via MRI (swiMRI), including deuterium MRI (dMRI) and .sup.17O MRI, for visualizing rapidly dividing immune cells within target and/or lymphoid organ/s and/or tissues affected by chronic graft-versus-host disease (cGVHD). Using deuterated water labeling, followed by dMRI, a distinction in deuterium signal was detected in a target organ (e.g. liver) of the cGVHD-affected mice compared to unaffected mice, i.e. syngeneic HSCT recipient mice, where the host and donor are matched, and normal (unmanipulated) mice.

A high-pressure magic angle spinning (MAS) rotor is detailed that includes a high-pressure sample cell that maintains high pressures exceeding 150 bar. The sample cell design minimizes pressure losses due to penetration over an extended period of time.

The present disclosure provides medical devices having MRI-compatible circuitry. Preferably, the devices do not project an enlarged profile, yet their position can be determined during an iMRI procedure. Illustrative embodiments of such a device can include a base surface, a first conducting layer disposed on the base surface, a first insulating layer disposed over at least a portion of the first conducting layer, and a second conducting layer disposed over at least a portion of the first insulating layer.

This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.

A coupling device is provided for coupling microwave radiation from a first microwave structure, in particular a microwave waveguide, into a second microwave structure, in particular a microwave resonant cavity, wherein the first and second microwave structures share a common wall, through an iris opening in said wall in front of which the coupling device is positioned on the side of the first microwave structure, in particular wherein the coupling device is of a basically cylindrical shape, characterized in that the coupling device comprises N electrically conducting conductor loops, with N≥3, preferably 3≤N≤20, that the conductor loops are arranged coaxially in an array along a z-axis, and that axially neighboring conductor loops are separated by a dielectric. The inventive coupling device allows for a larger coupling coefficient, and in particular allows for a larger dynamic range.

An electron-nuclear double resonance resonator, having a loop-gap resonator and an elongated lead; the loop-gap resonator comprises a plurality of arc-shaped conductive plates, and the elongated lead connects the arc-shaped conductive plates into a radio-frequency coil; the loop-gap resonator resonates at an electron resonance frequency, and the radio-frequency coil resonates at a nuclear resonance frequency; with the structure of the loop-gap resonator, the separation between an electric field and a magnetic field can be accelerated to ensure the maximization of the ratio of the magnetic field to the electric field inside a resonant resonator; and with the elongated lead, the impact of the lead to a resonance frequency and the mode of the loop-gap resonator is prevented as much as possible, and meanwhile the conductive plates of the loop-gap resonator can be connected into the radio-frequency coil.

A RF coil compression system for use with an MRI system configured to image a patient's breast is disclosed. In one embodiment, the compression system comprises a first compression plate comprising a first plurality of RF coil elements, which is positioned in a plane oriented orthogonal to a direction of the main magnetic field and the first RF coil elements having a reception sensitivity to a B1 field and is orthogonal to a main magnetic field of the MRI system. The compresses system may further comprise a second compression plate, configured to be positioned opposing the first compression plate and orthogonal to the superior-inferior direction, the second compression plate comprising a second plurality of RF coil elements, the second RF coil elements having a reception sensitivity to a B1 field oriented in a direction substantially orthogonal to the first direction and to the main magnetic field of the MRI system.

Various embodiments of the present disclosure are directed towards a radio frequency (RF) coil comprising a first combination coil and a second combination coil. The first combination coil comprises a first resonant coil and a first resonant shield coupled inductively or by a capacitor, and the first combination coil has a first resonant frequency and a second resonant frequency. The second combination coil comprises a second resonant coil and a second resonant shield coupled inductively or by a capacitor, and the second combination coil has a third resonant frequency and a fourth resonant frequency. The first and second resonant coils are inductively coupled to each other and respectively to the second and first resonant shields. The first and third resonant working frequencies are the same, and the second and fourth resonant isolation frequencies are such that inductive coupling between the first and second resonant coils is negated.