A sample residue collection device is provided. The sample residue collection device can include a housing, a nib, and a liquid or solvent configured for receipt within the nib. The housing can include a body, a nib housing, and an enclosure cap. The device can be configured for detection and identification of samples residues by colorimetric indications. The device can optionally include a solvent reservoir positioned within the body and containing at least a portion of the liquid or solvent. The solvent reservoir can be in fluid communication with the nib. The housing and nib with solvent may be single use or interchangeable and replaceable, providing a multiple use device. Related apparatus, systems, techniques, and articles are also described.

Disclosed herein a female hygienic device for diagnosing and/or monitoring cancer, comprising at least one absorption zone for accumulating vaginal discharge; and at least one indication zone comprising at least one agent for visually reacting with a physiological marker, the physiologic marker is indicative of a cancerous condition.

A reagent test paddle includes a contamination detection medium, a reference color bar, at least one chemical test medium, and a unique identifier. The contamination detection medium includes a reagent that changes color in the presence or when exposed to a hostile or inhospitable environment. Each chemical test medium includes a regent that is responsive to a respective analyte in a biological sample. The reference color bar includes reference color samples of different colors. The unique identifier, like a serial number, identifies the particular paddle and its chemical test medium so it can be uniquely and anonymously associated with a user. A method includes capturing and interpreting digital images of a biologically unexposed and subsequently exposed reagent test paddle at various delay times within an automatically calibrated environment; locating the paddle in a plurality of digital images, extracting the reference color bar and locating the contamination detection medium and chemical test medium in each digital image. Color changes of the chemical test medium and contamination medium are detected at various delay times after sample exposure. To determine validity of test results, the method further compares the detected colors of the contamination detection medium with predetermined colors expected for no contamination and contamination.

A computer implemented method of analysing assays performed at respective assay sites of an array or microarray that comprises a plurality of assay sites, the method comprising receiving at least one image of the assay sites of the array or microarray; for each of the assay sites, processing the at least one image to determine at least one metric representative of the degree of reaction at that assay site; for each of the assay sites, determining one or more parameters for that assay site, wherein the one or more parameters for at least one of the assay sites of the array or microarray are different from the one or more parameters for at least one other of the assay sites of the array or microarray; and for each of the assay sites, determining an extent of the reaction at that assay site from the at least one metric for that assay site and the one or more parameters for that assay site. Also disclosed is a correspondingly configured computerized analysis system.

An embodiment includes a sample receiving region, a first diagnostic element that includes one or more colorimetric analysis regions, and a second diagnostic element that includes one or more lateral flow assay analysis regions. The embodiment also includes a first flow path that allows a portion of a liquid deposited at the sample receiving region to flow to the first diagnostic element. The embodiment also includes a second flow path that allows a portion of the liquid deposited at the sample receiving region to flow to the second diagnostic element.

The present invention provides a dermal patch for selectively retaining one or more analyte(s) from a body of a subject comprising: a membrane layer (101) for retaining one or more analyte(s) from a body of a subject, with a first and a second side, wherein the first side is adapted to be in fluid communication with the skin of the subject; optionally holding means for securing the membrane layer in place; an adhesive layer (104); and a backing layer; wherein between the backing layer and the membrane layer (101) there is an expandable layer (103) for applying pressure to the membrane layer.

Transparent indicator tape is used for the detection of airborne chemicals in a suspect environment. In various embodiments, the indicator tape is affixed to a window or lens wherein one or more colorimetric indicators clad to the tape are exposed to the environment while humans or detection devices on the other side of the window or lens are not necessarily subjected to the suspect environment. In various embodiments the colorimetric indicator is sensitive to chemical warfare agents. Airborne chemicals including chemical warfare agents may detected by visual review or autonomous measurement of sensor color changes when in the presence of a target chemical. In various embodiments, the an indicator spot is split into sensitive and insensitive regions such that colorimetric changes may be more readily identified against a visually changing background.

An article of manufacture comprises an optical shade configured for removable attachment to eyewear, e.g., eyeglasses that are retrofitted to include a micro-fluidic tear collector in a nose pad. The optical shade comprises a lens having a lateral flow assay comprising an antibody having an associated fluorescent tag. The fluorescent tag is configured to fluoresce and change a color of the lens upon detection by the flow assay of an antigen that matches the antibody. The antigen comprises viral constituents, such as SARS-CoV-2. The color change of the lens is visible and indicates presence of Covid-19 infection.

An article of manufacture comprises an optical shade configured for removable attachment to eyewear, e.g., eyeglasses that are retrofitted to include a micro-fluidic tear collector in a nose pad. The optical shade comprises a lens having a lateral flow assay comprising an antibody having an associated fluorescent tag. The fluorescent tag is configured to fluoresce and change a color of the lens upon detection by the flow assay of an antigen that matches the antibody. The antigen comprises viral constituents, such as SARS-CoV-2. The color change of the lens is visible and indicates presence of Covid-19 infection.

Systems and indicators for determining the presence or absence of specific environmental, exposure, or biological conditions are provided. Indicators include a plurality of sensors, each sensor independently having a biological or chemical sensing modality to detect one or more analytes of interest. Analytes of interest include nucleic acids (e.g., DNA, RNA, etc.), proteins, peptides, and other amino acid chains and may come from a subject or the microbiome of a subject. The signals from the plurality of sensors may be processed to provide a readily understandable readout concerning a health condition or predisposition of a subject, such as cancer and exposure to coronavirus. The signals from the plurality of sensors may be colorimetric (e.g. a color change in response to the presence or absence of an analyte), and a plurality of colorimetric signals may be combined to provide a readily understandable colorimetric output. Indicators may be wearable.