Devices, methods for fabricating said devices, and methods for detecting an analyte within a bio-target are described herein. The device includes a top assembly and a bottom assembly. The Top assembly includes an electrode disposed on a top layer. The bottom assembly includes a bio-chip disposed on a bottom layer and a polymer body disposed between the bio-chip and the top assembly. The polymer body includes a channel. The electrode of the top assembly is positioned within the channel. The channel is configured to accommodate the bio-target containing the analyte.

Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprises at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

The present disclosure relates to biosensors (10) having a receptor layer (5) and a mediator layer (6), the receptor layer including ethylene receptor molecules. The present disclosure also relates to sensor units (20) comprising one or more biosensors (10) and a controller (11). In some embodiments, one or more sensor units (20) may be in wireless communication with a receiver module or a network gateway.

Disclosed are devices, systems and methods for monitoring one or more biomarkers using an electrochemical immunosensor sensor with an integrated enzymatic and immunosensing electrochemical detection capability. In some aspects, an electrochemical sensor device for monitoring glucose and insulin includes a substrate; and a plurality of electrodes disposed on the substrate, the plurality of electrodes including a first electrode to sense glucose, a second electrode to sense insulin, and a counter electrode to the first and second electrodes, in which the first electrode includes a glucose oxidase enzyme linked to a surface of the first electrode, and the second electrode includes an insulin capture antibody linked to a second electrode through a self-assembly monolayer, and in which, when the device is electrically coupled to an electronics unit, the device is operable to detect insulin and glucose from a fluid.

The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

Provided herein are devices (e.g., electrochemical sensors useful for detecting volatile organic compounds associated with certain diseases or conditions and/or diagnosing certain diseases or conditions). The devices comprise one or more layers of metal on a layer of silicon, and a layer of molecularly imprinted polymer in electrical communication with the one or more layers of metal, wherein the one or more layers of metal are each independently selected from a layer of chromium, platinum, gold, nickel, cobalt, tungsten, rhodium, iridium, silver, tin, titanium or tantalum, or an alloy thereof. Methods of using the devices (e.g., to detect one or more analytes in a sample, to detect and/or diagnose a disease or condition in a subject), and methods of making the devices are also provided.

A method of DNA base-calling from a nanochannel DNA sequencer. The method includes building a reference map and preparing an unknown sequence of DNA prior to the final step of data matching. The reference map includes a series of reference characters, such as numbers, that describe the change in tunneling current of a DNA strand with a known sequence. A DNA strand of unknown sequence is prepared so that the change in electrical measurement can also be described numerically. The section of match between the DNA strand of unknown sequence and the reference map is used to determine the sequence of the DNA strand.

Development of a technique that is intended to modify, stabilize, functionalize, and reuse the surface of screen-printed electrodes, by means of the application of Rhodamine 6G as a working area modifying organic compound, enabling the creation of immunosensors that use proteins or their biological or synthetic fragments, antigens, antibodies, peptides, DNA, enzymes, RNA, and aptamers as analytes or as an element of biological recognition.

A system for determining a level of hematocrit includes a test strip configured to receive a sample; a meter configured to receive the test strip; and further including circuitry and a microprocessor, the circuitry and microprocessor configured to apply electrical energy to the test strip and the sample and determine an electrical property of the sample, either the impedance phase angle or the impendence magnitude of the test strip and the sample and, based on the electrical property, calculate the level of hematocrit in the sample.

Examples of the disclosure relate to apparatus, methods and computer programs for analysis of biological samples. The apparatus comprising means for: obtaining a model representing electrical properties of a biological sample where the biological sample comprises a plurality of different cell types and the model comprises a plurality of different sub-circuits where the sub-circuits represent individual structures within cells of the biological sample such that the sub-circuits have electrical properties corresponding to the electrical properties of the cells; using the obtained model to determine expected output signals obtained in response to an electrical signal provided between two or more electrodes positioned on the biological sample; and using the expected output signals to adjust one or more settings of the electrodes.