The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a system includes a user interface and processing circuitry. The processing circuitry is configured to output, for display by the user interface, a message requesting the patient perform a set of actions, receive, from the user interface, user input indicative of a patient response associated with the set of actions, and determine, based on the user input, one or more adjustments to a control policy which controls electrical stimulation delivered by a medical device based on a plurality of evoked compound action potentials (ECAPs) sensed by the medical device.

Generally discussed herein are systems, devices, and methods for providing a therapy (e.g., stimulation) and/or data signal using an implantable device. Systems, devices and methods for interacting with (e.g., communicating with, receiving power from) an external device are also provided.

An implant that includes an electrode is advanced to a nerve of a subject using a tube. The tube and the implant are arranged at a nonzero angle with respect to a skin surface of the subject, and the implant is passed distally from an opening of the tube, in a vicinity of a portion of the nerve. A longitudinal axis of the implant is realigned to become generally parallel with the skin surface, by proximally withdrawing the tube from the subject. Other embodiments are also described.

A capacity-expanding separated interface nerve electrode (SINE) can be used to deliver a nerve conduction block to one or more nerves. The SINE can include a source electrode coupled to a waveform generator. The source electrode can deliver an electrical neuromodulation signal (e.g., a direct current (DC) signal) to an ionically conductive medium. The SINE can also include a vessel holding the ionically conductive medium, which can include a material that facilitates a transformation of the electrical neuromodulation signal to an ionic neuromodulation signal with a high charge capacity. The SINE can also include a nerve interface that can deliver the ionic neuromodulation signal to a nerve. The SINE can be used in combination with a return electrode that is also coupled to the waveform generator.

Nerve cuff deployment apparatuses and methods of using them to deliver a nerve cuff electrode to a target nerve trunk.

Disclosed are platforms to enable lower impedance electrode array, together with a miniaturized battery pack. Lower impedance can be achieved by different approaches, according to the invention, including surface modifications, preferably in nanoscale. Also disclosed are articles and control systems comprising medical implant neural stimulator devices, neural diagnosis tools, spinal cord and peripheral nerve stimulations, and cochlear implants. More particularly, the invention discloses means for reducing pains in human body, utilizing innovative components and systems comprising an epidural lead having multiple electrodes at a distal end, the electrodes being configured in an array and being selectable to provide either unilateral or bilateral neural stimulation. In an example, advanced spinal cord stimulation (SCS) electrodes having pre-designed novel, metallic or non-metallic nanostructured surface with desirable high-aspect-ratio nanopillar features for superior neural electrode functionality exhibiting significantly reduced electrical impedance are disclosed.

A test fixture (20) for testing continuity in at least one electrode of a neuromodulation device. The test fixture may comprise a substrate (22), at least one electrically conductive pad (24a) disposed on the substrate for reducing pressure applied to the at least one electrode when the electrically conductive pad makes contact with an exposed surface of the electrode, and a wire (26a) extending from the at least one electrically conductive pad. The pad may be formed of a non-abrasive material, such as conductive foam or smooth metal. The substrate may be a probe formed with a number of slots for holding pads and routing wires, a mandrel with openings for holding pads and routing wires, and a flexible circuit with exposed smooth metal surfaces. The test fixture may be suitable for testing cuff-like and paddle-like devices.

Modulation, preferably inhibition, of neurosignaling of a cardiac-related sympathetic nerve in the extracardiac intrathoracic neural circuit is effective in stabilizing cardiac electrical and/or mechanical function, thereby providing ways of treating or preventing cardiac dysfunction such as arrhythmias.

A system for controlling urination in a patient includes an implantable controller and an external device. The implantable controller includes circuitry and electrodes for stimulating the pudendal nerves in order to control urination. In addition, the implantable controller includes sensors for determining information on bladder fullness and for transmitting such information to an external device which is used for controlling the implanted controller. The external device will display when bladder filling exceeds a safe threshold level, allowing the patient and a caregiver to take appropriate steps to allow the patient to urinate.