Disclosed herein is a vaccine comprising an antigen and IL-21. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.

The present invention relates to a composition comprising a matrix and a carrier encapsulating a therapeutic compound, wherein the matrix is configured to release the therapeutic compound under an ultrasound stimulus. A wound dressing includes the composition is also disclosed. The therapeutic compound can be released by being exposed to an ultrasound stimulus.

Disclosed herein is a therapeutic comprising hypoxia inducible factor-1 alpha (HIF-1). Also disclosed herein is a method for treating hypoxia or ischemia in a subject in need thereof. The method may comprise administering the vaccine to the subject in need thereof.

The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.

The present invention relates to a method for the treatment of cancer in a subject which comprises the steps of: (i) administering electroporation to a tumour in the subject; and (ii) administering a T or B-cell activating agent to the subject, wherein step (i) and (ii) may be performed in either order.

The invention is modified transdermal patch, which contains two or more absorbent pads placed atop one another within the drag reservoir of the patch, enabling the patch to (1) hold a greater quantity of the drag, (2) extend the useful life of the patch, (3) enhance the quantity of the dose which can be released from the patch, by either passive of active methods of drag release.

The invention is a device for transmitting acoustical energy between an ultrasonic generator, through a medicine-containing patch, and into the exterior surface of the skin of a patient, typically known as an ultrasonic transducer. The ultrasonic transducer emits a sonic transmission of variable intensity and frequency for the purpose of enhancing the absorption through the patient's skin of pharmaceutical compounds stored within a transdermal patch or other medication holding device. The transducers are designed to accommodate an ultrasonic drug delivery system, which is worn by the patient.

The invention is a means to provide enhanced delivery of a drug from a transdermal patch, employing a screen filter at the bottom of the patch which contacts the skin. The screen filter enables the drug from the patch to become deposited onto the surface of the skin in a series of droplets, spaced in such a manner as to match the skin's pores. The drop deposition of the patch increases the speed of delivery of the patch, whether an active or a passive patch form.

Several embodiments disclosed herein relate to the delivery of therapeutic nucleic acids to an ocular tissue in order to provide a therapeutic effect to reduce symptoms of or otherwise alleviate an ocular disorder. In particular embodiments, plasmid DNA is delivered to the cells of the trabecular meshwork in order to ameliorate increasing intraocular pressure. Devices and systems to accomplish this delivery are also disclosed.

Provided are a stem cell-nano anticancer drug complex in which an anticancer drug based on carbon nanotubes (CNT) and gold (Au) nano particles is loaded on the surface of stem cells, which can overcome side effects of conventional stem cells and targeting limitations of nano anticancer drugs and whose anticancer effect is very excellent, the use thereof, and a method for preparing the same.