An embodiment includes a system comprising: a catheter; an optic fiber having a long axis and a short axis that is orthogonal to the long axis; first and second radiopaque elements coupled to the optic fiber; a first wire coupled to the optic fiber and extending from the first radiopaque element to the second radiopaque element; a fluid; wherein (a)(i) the first wire wraps at least partially around an exterior surface of the optic fiber; (a)(ii) an outer diameter of the first wire and an outer diameter of the optic fiber are collectively less than an inner diameter of the catheter, and (a)(iii) the first wire is configured to center the optic fiber within the catheter within a plane orthogonal to the long axis.

An implant (1) for the treatment of arteriovenous deformities, in particular aneurysms (2). In an expanded state the implant has a basic body (6) comprising of a proximal and a distal segment (7, 8), with the proximal and the distal segment (7, 8) being of dome-shaped configuration, with the convex side of the dome of the proximal segment (7) facing in the proximal direction and the convex side of the dome of the distal segment (8) facing in the distal direction, and wherein the proximal and the distal segment (7, 8) are connected to each other via a plurality of connecting struts (9). Alternatively, the implant (1) may have the shape of a closed tulip blossom. The inventive implant (1) is able to adapt well to the shape of the respective aneurysm (2).

A biodegradable flow diverting device (BFDD) that will regulate blood flow into an aneurysmal sac, act as a scaffold for endothelization at the neck of an aneurysm, and degrade after successful dissolution of aneurysm and remodeling of blood vessel. This BFDD and associated fabrication method have the following features: (1) This is a non-braided FDD. The pore shapes, sizes, architectures (especially at the inlet and outlet of the pores), pore densities and porosities can be controlled for the optimum performance depending on the blood vessel and aneurysmal morphologies from patient MRI images, (2) BFDD is developed on a rotary arm with programmable variable speed and diameter in conjunction with a micromotion stage (3) Fabrication system can take any material including blended/composite biomaterials by adjusting temperature of the electro-melt extruder/needle and (4) Fabrication system is compatible with CAM (computer aided manufacturing) software and able to operate based on the adapted G-code.

Disclosed herein is an intrasacular aneurysm occlusion device with a linearly-aligned proximal-to-distal stack of embolic structures which is configured to be inserted into an aneurysm sac and then radially-expanded and longitudinally-contracted. The stack can be shaped like a 3D revolution of three single phases (or one and half full phases) of a sine wave around its central longitudinal axis. There can be openings in the stack which allow insertion of embolic material (e.g. coils, hydrogels, or congealing material) into the embolic structures.

What is disclosed are medical devices comprising a rounded, thin-walled, expandable metal structure (“ballstent”) and a flexible, elongated delivery device (“delivery catheter”) and systems and methods of use for treating saccular vascular aneurysms with the medical devices. Ballstents comprised of gold, platinum, or silver that can be compressed, positioned in the lumen of an aneurysm, and expanded to conform to the shape of the aneurysm are disclosed. The external surface of ballstents can be configured to promote local thrombosis and to promote the growth of tissue into and around the wall of the ballstent in order to seal the aneurysm and fix the ballstent in place in the aneurysm. The wall of the ballstent can also be configured to release drugs or pharmacologically active molecules, such as those that promote thrombosis, cell proliferation, extracellular matrix deposition, and tissue growth.

Methods for treatment of a cerebral aneurysm within a cerebral vasculature of a patient are described. A microcatheter and a device for treatment of the aneurysm are provided. The device is a self-expanding resilient permeable shell having a plurality of elongate resilient filaments with a woven structure. The plurality of filaments includes small and large filaments. The filaments are bundled and secured to each other at a proximal end. A ratio of the total cross-sectional area of small filaments to the total cross-sectional area of large filaments may be between 0.56 and 1.89. The distal end of the microcatheter is advanced to a region of interest within a cerebral artery. The device is advanced through the lumen and out of the distal end of the microcatheter such that the permeable shell deploys and expands within the cerebral aneurysm. The microcatheter is then withdrawn from the cerebral artery.

The present invention relates generally to systems and methods for delivering embolic devices into a body lumen of a patient. These embolic devices are applicable to a variety of neurological and/or peripheral applications. In particular, the embolic devices may be used to occlude a vessel within a patient, and/or to treat aneurysms, arteriovenous malformations, traumatic fistulas, uterine fibroids or cancer.

A method is described herein for the treatment of intracranial aneurysms. The method comprises inserting into an aneurysm an embolism coil coated with a polymeric coating comprising a genipin, such as genipin or a derivative thereof, thereby increasing the stability of clots within the aneurysm. According to one example, the coating is a poly(L-lactide-co-glycolide) (PLGA) is used to release genipin to crosslink fibrin clots thereby creating more stable occlusions. Increased clotting can improve segregation of the weakened portion of the blood vessel from the rest of the vasculature and reduce the risk of recurrence.

A system for delivering a device into a body lumen of a patient, the system including a device having a marker band and a tube at a proximal portion, and a pusher member having a ribbon and a ball or hook at a distal portion of the delivery member and a compression coil positioned over the ribbon, the ball or hook releasably engageable with the tube.

The present invention provides for implant device delivery apparatuses and related methods of use. The delivery systems of the present invention incorporate a stretch resistant tube that advantageously makes the implant device, such as an embolic coil, stretch resistant while a delivery system is being used to position the implant device at a desired target site.