Patent classifications
A61K49/1884
Rod-shaped plant virus nanoparticles as imaging agent platforms
A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
HSP90-TARGETED INFLAMMATION AND INFECTION IMAGING AND THERAPY
The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.
ROD-SHAPED PLANT VIRUS NANOPARTICLES AS IMAGING AGENT PLATFORMS
A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
HSP90-TARGETED INFLAMMATION AND INFECTION IMAGING AND THERAPY
The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.
HSP90-targeted inflammation and infection imaging and therapy
The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.
Rod-shaped plant virus nanoparticles as imaging agent platforms
A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
HSP90-TARGETED INFLAMMATION AND INFECTION IMAGING AND THERAPY
The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.
Hsp9O-targeted inflammation and infection imaging and therapy
The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.
FLUORINATED FIBERS FOR MULTIMODAL 1H AND 19F MRI, ULTRASOUND, FLUORESCENCE DETECTION AND CONFORMATIONAL AND TEMPERATURE DETECTION BY 19F MRS
Provided are proteins/peptides. The proteins or peptides comprise a sequence designed by the methods described herein. The proteins and peptides may have one or more trifluoroleucine (L.sub.TF, which may be referred to as TFL or LTF throughout) residues. The proteins may have or contain the following sequence: VX.sub.1X.sub.2X.sub.3X.sub.4X.sub.5X.sub.6X.sub.7X.sub.8X.sub.9X.sub.10X.sub.11X.sub.12X.sub.13X.sub.14X.sub.15X.sub.16X.sub.17X.sub.18X.sub.19X.sub.20X.sub.21X.sub.22X.sub.23X.sub.24X.sub.25X.sub.26X.sub.27X.sub.28X.sub.29X.sub.30X.sub.31X.sub.32X.sub.33X.sub.34X.sub.35X.sub.36X.sub.37 (SEQ ID NO:1), where X.sub.1 is A, E, D, R, H, K, Q, N, or S; X.sub.2 is A, E, N, or Q; X.sub.3 is A, V, L, I, Q, M, or L.sub.T; X.sub.4 is A, E, R, D, H, I, L, T, K, Q, N, or L.sub.T; X.sub.5 is A, F, Q, R, K, H, D, S, or E; X.sub.6 is A, L, I, or L.sub.TF; X.sub.7 is A, K, or E; X.sub.8 is A, K, E, D, R, H, Q, or N; X.sub.9 is A, T, I, L, Q, or L.sub.TF; X.sub.10 is A, L, I, or LT; X.sub.11 is A, E, D, H, P, I, L, K, Y, N, Q, R, or LT; X.sub.12 is A, Q, H, E, D, K, R, or N; X.sub.13 is A, M, I, L, Q, T, or L.sub.TF; X.sub.14 is A, L, D, E, K, I, or L.sub.TF; X.sub.15 is A, E, D, H, Y, I, L, R, K, Q, N, or Lu; X.sub.16 is A, E, or Q; X.sub.17 is A, L, M, I, V, or L.sub.TF; X.sub.18 is A, K, E, D, K, R, H, N, or Q; X.sub.19 is A, N, D, K, R, H, Q, or E; X.sub.20 is A, L, T, I, M, R, or L.sub.TF; X.sub.21 is A, N, or Q; X.sub.22 is K, A, E, I, L, M, R, H, D, Q, N, S, or L.sub.TF; X.sub.23 is A, Q, N, I, L, or L.sub.TF; X.sub.24 is A, L, I, M, T, or LT; X.sub.25 is A, H, Q, R, K, D, N, Y, I, E, L, T, or LT; X.sub.26 is A, D, E, R, K, Q, H, N, or T; X.sub.27 is A, V, I, Q, L, T, or L.sub.TF; X.sub.28 is A, R, E, D, K, H, N, Q, or T; X.sub.29 is A, H, E, R, D, K, I, L, N, Q, T, Y, or L.sub.TF; X.sub.30 is L, A, D, K, I, N, Q, or L.sub.TF; X.sub.31 is A, L, Q, I, or L.sub.TF; X.sub.32 is E, D, K, H, N, Q, A, L, R, I, Y, or L.sub.TF; X.sub.33 is A, N, Q, D, E, H, K, R, or S; X.sub.34 is Q, I, L, A, M, or LT; X.sub.35 is S, A, P, or Q; X.sub.36 is A, K, T, D, R, H, N, Q, or E; X.sub.37 is A, L, I, K, D, N, Q, R, or L.sub.TF; where at least one of X.sub.3, X.sub.4, X.sub.6, X.sub.9, X.sub.10, X.sub.11, X.sub.13, X.sub.14, X.sub.15, X.sub.16, X.sub.17, X.sub.20, X.sub.22, X.sub.23, X.sub.24, X.sub.25, X.sub.27, X.sub.29, X.sub.30, X.sub.31, X.sub.32, X.sub.34, X.sub.37 or any L is replaced with L.sub.TF. The proteins and peptides may have desirable self-assembling properties such that they form supramolecular structures (e.g., fibers or fibrils). The supramolecular structures may further gelate water such that a hydrogel is formed. The fibers and/or gels may be used to delive
ROD-SHAPED PLANT VIRUS NANOPARTICLES AS IMAGING AGENT PLATFORMS
A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.