A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a first chamber with an inner cavity including a first constituent and an outer cavity concentric with the first cavity and including a second constituent. A partition can be openable and separate the first and second cavities. A second chamber can include a third constituent and be concentric with the first chamber. Moving the first chamber and/or the second chamber relative to the other can cause the partition to open so that the first constituent and the second constituent mix with each other to form a first mixture. Applying a force to the system can cause the first mixture and the third constituent to egress through distal portions of the first and second chambers and mix together to form the mixture for delivery to the treatment site.

Provided are methods and devices for dissolving solid protein compositions, such as solid compositions comprising fibrinogen, in an aqueous solvent. The methods comprise use of a closed container containing a volume of solid fibrinogen composition and a head space wherein the pressure within the headspace is sub-atmospheric. Aqueous solvent is introduced into the container while maintain the sub-atmospheric pressure, and subsequent to addition of the solvent, the size of the headspace is decreased to bring the pressure to atmospheric pressure. The devices are suitable for use in the disclosed method.

One embodiment relates to a device for the production of a bone cement dough from a monomer liquid and a cement powder comprising a cartridge with an internal space; a cartridge head with a dispensing opening; a conveying plunger that is arranged in the internal space of the cartridge and is supported in the internal space of the cartridge such that it is pushable in the direction of the dispensing opening; a dispensing plunger between the dispensing opening and the conveying plunger that is supported in the internal space of the cartridge such that it is pushable in the direction of the dispensing opening; a first hollow space, in which the cement powder is arranged; a second hollow space that is bordered by the dispensing plunger and the conveying plunger; a fluid opening that is arranged in the conveying plunger; a feedthrough that connects the first hollow space and the second hollow space to each other, and a closure means that is arranged on a rear side of the dispensing plunger. The closure means projects away from the dispensing plunger and is situated at a distance from the fluid opening. The fluid opening is closable with the closure means. The closure means is mobile in the closed fluid opening such that the fluid opening stays closed, while the conveying plunger is pushable further in the direction of the dispensing plunger.

The invention provides a bone cement mixing assembly including a mixer, a syringe barrel and a movable plug cover. The mixer includes a stirring rod and a stirring barrel. The stirring rod has holding end, a rod body and a stirring end. The stirring barrel has a barrel cover, a first barrel open, a first barrel body, a first barrel bottom, and a stirring space located in the first barrel body. The syringe barrel has a second barrel open, a second barrel body, a second barrel bottom, and an injection space located in the second barrel body. In this way, the complete-stirred bone cement in the stirring barrel can be directly collected and pushed into the syringe barrel through the movement of the movable plug cover to achieve the effect of completing the preparation of the bone cement quickly and efficiently.

The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

A dynamic mixer for mixing a multi-component material includes a mixing rotor capable of being rotated about an axis of rotation, the mixing rotor having a coupling socket configured at an end thereof. The coupling socket has a reception space configured to receive at least a part of a polygonal shaped coupling plug of a drive shaft to transfer torque from the drive shaft to the mixing rotor. The reception space has an inner length in the direction of the axis of rotation and has an inner surface extending over the inner length and surrounding the axis of rotation.

A method of applying a two-part dental sealant is described comprising providing a syringe device (1) comprising a cartridge (10) including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle (17) comprising a static mixer and an outlet at one end of the cartridge and a plunger (20) at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.

A container with two inner chambers (6, 7) running in its longitudinal direction and separated by at least one partition wall. An aerobic adhesive is stored in one inner chamber (6). A hydrophilic, gel-like activator is stored in the other inner chamber (7); a mixing unit can be attached to the front end of the container. The aerobic adhesive is fed to the mixing unit from the first inner chamber (6), and the hydrophilic activator is fed to the mixing unit from the second inner chamber (7), in a specified mixing ratio via a supply device and mixed together there. This mixture is discharged via an outlet opening (13) of the mixing unit.

A device stores, mixes, and applies polymethylmethacrylate bone cement. The device comprises a first container for a first pasty component of the bone cement, a dispensing plunger arranged in the first container such that it can be shifted and serves for pressing the content of the first container out of a dispensing opening, a mixing facility for mixing the content of the first container, whereby the mixing facility is arranged in the first container and the mixing facility can be moved in the first container from outside for mixing, and at least one second container for at least one second component of the bone cement is arranged in or on said first container. The second container can be opened, such that the contents of the first container and second container can be mixed with each other in the first container, whereby at least a boundary surface of the first container is formed by a mobile volume compensation element.

A mixing impeller (10) for mixing a sealant inside a cartridge (1) is disclosed. The mixing impeller (10) comprises a central hub (11) and at least two mixing arms (20) extending radially outward from the central hub (11). Each of the mixing arms (20) may include a leading edge (24), a trailing edge (26), and a wiping edge (28) extending circumferentially between a leading tip (25) of the leading edge (24) and a trailing edge transition (27) of the trailing edge (26). The wiping edge (28) may have an arc length defining a wiping edge (28) angle, the leading tip (25) may be circumferentially offset in a direction of rotation of the mixing impeller (10) defining a leading edge (24) angle to provide a forward swept configuration, and the wiping edge (28) angle may be greater than the leading edge (24) angle. A sealant cartridge (1) and mixing impeller (10) assembly is also disclosed.