Systems and methods for multi-chambered syringes are described. In some embodiments, a multi-chamber syringe includes a housing with an internal cavity and first and second plungers disposed at least partially within the internal cavity. The first and second plungers are slidably displaceable relative to the housing, and are associated with first and second chambers respectively. A barrier is disposed at least partially between the first and second plungers to form the first and second chambers. The barrier is slidably displaceable relative to the plungers and barrel to selectively place the first and second chambers including first and second materials respectively in fluid communication. When the barrier is displaced, the first and second materials mix in a combined volume of the first and second chambers. Displacing the first plunger, the second plunger, and the barrier may dispense the mixed materials from the combined volume.

A static mixer 10 for mixing a fluid flow having at least two components is disclosed, as well as a method for mixing first and second components with the static mixer 10. The static mixer 10 includes a mixing conduit 20 having a first inner surface 38a, a second inner surface 38b that extends from the first inner surface 38a, and a third inner surface 38c that extends from the first inner surface 38a to the second inner surface 38b. The first, second, and third inner surfaces 38a, 38b, 38c define a mixing passage receiving the fluid flow. The first and second inner surfaces 38a, 38b are offset by a first acute angle, the first and third surfaces 38a, 38c are offset by a second acute angle, and the second and third surfaces 38b, 38c are offset by a third acute angle. The static mixer 10 includes a mixing element 100 positioned in the mixing passage.

One aspect relates to a bone cement applicator having a cartridge with an interior, a cartridge head with a delivery opening, a mixing member which is movable in the interior with a mixing rod. A delivery plunger is arranged in the cartridge and is mounted in the interior and is pressable in the direction of the delivery opening. The delivery plunger rests with an outer cylindrical circumferential surface against an inner wall of the cartridge. A clamping element is arranged on the inner wall of the cartridge in the region of a back side of the interior. The clamping element projects out of the inner wall of the cartridge. The cylindrical circumferential surface of the delivery plunger is resiliently deformable by the clamping element in the direction of a central cylinder axis, such that the delivery plunger is clampable in place with the at least one clamping element on the back side of the cartridge.

A medical device for making foam includes a syringe having a plunger for dispensing a liquid from a liquid dispensing port, and a mixing chamber including a mixing chamber inlet, a mixing chamber outlet, a liquid flow channel extending between the mixing chamber inlet and the mixing chamber outlet, and a gas inlet channel that intersects with the liquid flow channel. The system has a gas cartridge containing the gas, a first gas conduit connected with the syringe, and a second gas conduit connected with the gas inlet channel. An actuator is coupled with the gas cartridge for releasing the gas into the first and second gas conduits. The released gas in the first gas conduit forces the plunger toward the liquid dispensing port for dispensing the liquid from the liquid dispensing port and into the liquid flow channel while the released gas in the second gas conduit flows into the gas inlet channel of the mixing chamber for mixing with the liquid in the liquid flow channel.

A liquid-liquid mixing device (10, 210) includes a barrel (20, 220) with a liquid port (23) at or adjacent one end. A plunger assembly (30) is reciprocably moveable along an axis in the barrel (20, 220) and includes a seal member (31, 231) and an agitator (50, 250). The seal member (31, 231) is in sealingly slidable engagement with the internal wall of the barrel (20, 220) to define a variable volume chamber (24, 224) therein in communication with the liquid port. The agitator (50, 250) is reciprocably moveable in the variable volume chamber (24, 224), which agitator (50, 250) includes one or more end to end passages (54) through which liquid in the chamber (24, 224) is forced as the agitator (250) reciprocates in the chamber (24, 224). The device (10) also includes a mode selector mechanism (60, 28, 46, 64, 65, 90, 92, 94, 96) for selection between at least two modes of operation for the plunger assembly, wherein the mode selector mechanism (60, 28, 46, 64, 65, 90, 92, 94, 96) is adjustable between two or more modes whereby movement of the plunger assembly (30) effects either movement of the agitator (50, 250) with the seal member (31, 231) or movement of the agitator (50, 250) relative to the seal member (31, 231), depending on the selected mode.

Device for the mixing of polymethylmethacrylate bone cement and for storing a monomer liquid and a cement powder as starting components of the bone cement, comprising a cartridge having an internal space closed on one side by a mobile dispensing plunger; a monomer container for a monomer liquid and/or a connector for attachment of a monomer container which can be opened in the device so that the monomer liquid flows from the monomer container into the device; and a connecting conduit through which the monomer liquid can be guided into the internal space of the cartridge; having a pumping plunger that can be shifted axially in the hollow cylinder arranged in the hollow cylinder, which can be used to push monomer liquid from the hollow cylinder through the connecting conduit into the internal space of the cartridge by actuating the pumping plunger.

A device for providing a bone cement dough from two starting components, comprising a hollow cylindrical cartridge with an interior space, wherein a bone cement powder as the first starting component is stored in a proximal part of the interior space, and at least two pouches containing a monomer liquid as a second starting component are stored in a distal part of the interior space, wherein a dispensing plunger axially movable in the interior space is arranged between the bone cement powder and the at least two pouches, and a delivery plunger axially movable in the interior space is arranged on a side of the at least two pouches that is axially opposite the dispensing plunger, wherein the proximal part and the distal part of the interior space are fluidically connected to one another via a conduit means.

An automatic nucleic acid extraction cartridge and an automatic nucleic acid extraction system including the same are described herein. The cartridge having a housing that includes a sample port, a cell processing chamber, a wash fluid chamber, a filter assembly comprising a filter member, and a diverter valve having a first and a second reversibly sealable output, wherein each of the sample port and the cell processing chamber, the cell processing chamber and the filter assembly, and the wash fluid chamber and the filter assembly are in one-way fluid communication, and the filter assembly is in fluid communication with the diverter valve and (i) a waste conduit when the diverter valve is biased to the first reversibly sealable output and (ii) a pathogen nucleic acid conduit when the diverter valve is biased to the second reversibly sealable output. The present disclosure further describes methods of using the same.

A mixing tip for mixing multi-component materials exiting a multi-component cartridge includes a code that is stored in or at the mixing tip indicating at least one of a type of mixing tip, a manufacturer of the mixing tip, a date of production of the mixing tip and a list of materials compliant with the mixing tip.

An apparatus for providing a liquid component as a first starting component of a bone cement dough from two starting components, comprising a receptacle in which a tank containing the liquid component can be stored, an opening means for opening the tank, a reservoir, fluidically connected to the receptacle, for receiving the liquid component from the tank, at least one port for fluidically connecting the apparatus to a syringe in which a powder component can be stored as a second starting component of the bone cement dough, and at least one conducting means which fluidically connects the reservoir and the at least one port to one another.