Provided are a concentration measuring method of an optically active substance and a concentration measuring device of an optically active substance, which can easily and accurately measure a concentration of the optically active substance in aqueous humor. The concentration measuring method of an optically active substance includes: a first step of measuring a polarization state of a first reflected light that is obtained by irradiating an aqueous humor in an eye with an incidence light which is polarized and reflecting the incidence light at an interface between the aqueous humor and a lens, in which the polarization state of the first reflected light is measured by irradiating a first incidence light such that an angle between a normal line to a point where the incidence light intersects a surface of the lens, and the incidence light is equal to or smaller than a Brewster angle; a second step of measuring a polarization state of a second reflected light by irradiating with a second incidence light such that an angle of the incidence light is equal to or larger than the Brewster angle; a third step of calculating an optical rotation of the aqueous humor with information on the polarization state of the first reflected light and information on the polarization state of the second reflected light; and a fourth step of calculating a concentration of an optically active substance in the aqueous humor from the optical rotation of the aqueous humor.

A monitoring system and method are presented for use in monitoring a target. The monitoring system comprises: an input utility for receiving input data comprising measured data indicative of optical response of the target measured under predetermined conditions and comprising phase data indicative of a two-dimensional profile of full phase of the optical response of the target in a predetermined two-dimensional parametric space including a two-dimensional range in which said target exhibits phase singularity; an analyzer module for processing said measured data and extracting at least one phase singularity signature of the target characterizing the target status, the phase singularity signature being formed by a number N of phase singularity points, each corresponding to a condition that the physical phase continuously accumulates a nonzero integer multiple m of 2π around said point.

An analyzing system is provided. The analyzing system includes a fluid container defining a sample chamber where a sample is contained in the sample chamber, and a sensor including a transparent body with a reverse face and an obverse face where the obverse face having a nanostructured surface. The nanostructured surface includes a plurality of elongate nanostructures having a respective longitudinal axis that is disposed substantially perpendicularly to the obverse face. The analyzing system includes an excitation and detection apparatus that includes an excitation source for generating a beam of polarized radiation and a corresponding radiation detector where the sensor is coupled to the fluid container such that the nanostructured surface is exposed to the sample chamber, to the sample located therein.

An ellipsometer capable of improving a throughput calculating ellipsometry coefficients (ψ, Δ) even when performing measurement with a combination of a light source having a wide wavelength band and a spectrometer, and an apparatus for inspecting a semiconductor device is e hid g the ellipsometer may be provided. The ellipsometer includes a polarizing optical element unit for separating reflected light into two polarization components having polarization directions that are orthogonal to each other in a radial direction with respect to an optical axis of an optical system of the reflected light, an analyzer unit for transmitting components of a direction different from the polarization directions of the two polarization components to make the two polarization components interfere with each other, and to form an interference fringe in a form of a concentric circle, an image detector for detecting the interference fringe, and processing circuitry for calculating ellipsometry coefficients from the interference fringe.

A device for identifying water on a surface, including an optical sensor and a processor. The optical sensor is configured to produce a first image of the surface which has a first optical bandwidth within which the water has a first absorption rate, and a second image of the surface which has a second optical bandwidth within which the water has a second absorption rate that is higher than the first absorption rate. The processor is configured to combine the first image and the second image to produce a combined image in which the surface is reduced or eliminated as compared to the water. In addition, the processor is configured to detect water in the combined image.

An angle independent optical surface inspector capable of generating a light beam, directing the light beam to a sample, and de-scanning a reflected light beam that is reflected from the sample, thereby generating a first de-scanned light beam. The de-scanning is performed at approximately one focal length of a de-scanning lens from an irradiation location where the light beam irradiates the sample. The optical inspector also capable of focusing the first de-scanned light beam, thereby generating a focused light beam, and measuring the location of the focused light beam. The measuring of the location is performed at approximately one focal length of a focusing lens from the focusing lens. The incident angle of the light beam is within ten degrees of Brewster's angle. The focusing is performed by an achromatic lens.

The present chip relates to a high-sensitive biosensor chip using a high extinction coefficient marker and a dielectric substrate, a measurement system, and a measurement method and, more specifically, to an ellipsometry-based high-sensitive biosensor technology or a measurement method using same, the technology amplifying an elliptically polarized signal by a marker having a high extinction coefficient and a dielectric substrate. The marker and the substrate used in the present chip measure a Brewster's angle shift or an elliptical polarization measurement angle with respect to an ultra-low concentration biological material (e.g. antibody or DNA).

A device for identifying water on a surface, including an optical sensor and a processor.

The optical sensor is configured to produce a first image of the surface which has a first optical bandwidth within which the water has a first absorption rate, and a second image of the surface which has a second optical bandwidth within which the water has a second absorption rate that is higher than the first absorption rate.

The processor is configured to combine the first image and the second image to produce a combined image in which the surface is reduced or eliminated as compared to the water. In addition, the processor is configured to detect water in the combined image.

A monitoring system and method are presented for use in monitoring a target. The monitoring system comprises: an input utility for receiving input data comprising measured data indicative of optical response of the target measured under predetermined conditions and comprising phase data indicative of a two-dimensional profile of full phase of the optical response of the target in a predetermined two-dimensional parametric space including a two-dimensional range in which said target exhibits phase singularity; an analyzer module for processing said measured data and extracting at least one phase singularity signature of the target characterizing the target status, the phase singularity signature being formed by a number N of phase singularity points, each corresponding to a condition that the physical phase continuously accumulates a nonzero integer multiple m of 2 around said point.

The present chip relates to a high-sensitive biosensor chip using a high extinction coefficient marker and a dielectric substrate, a measurement system, and a measurement method and, more specifically, to an ellipsometry-based high-sensitive biosensor technology or a measurement method using same, the technology amplifying an elliptically polarized signal by a marker having a high extinction coefficient and a dielectric substrate. The marker and the substrate used in the present chip measure a Brewster's angle shift or an elliptical polarization measurement angle with respect to an ultra-low concentration biological material (e.g. antibody or DNA).