Methods, apparatuses, and systems associated with a sample testing device are provided.

The invention relates to an optic fiber having a core in which carbon nano-structures are formed at a predetermined locus, a fiber optic chemical sensor using the optic fiber, and a method of forming the carbon nano-structure layer in the core of the optic fiber. The invention utilizes gas refractive index and the adsorption sensitivity of particles on the surface of the carbon nano-structure layer, and uses the carbon nano-structure layer in the core of the optic fiber as a sensor for particles of gas, liquid and the like.

An optical sensor has a substrate with first and second sides, one side being provided with first and second waveguides. The first and second waveguides have respective first and second measuring points along their respective lengths, each measuring point includes at least one interruption. The first measuring point, which belongs to the first waveguide, is functionalized by at least one coating while the second measuring point, which belongs to the second waveguide, is not functionalized by that same coating. The functionalized coating may include a substance (e.g., antibody) which corresponds to a pathogenic germ. A light source may simultaneously direct light into both waveguides and a light detector may simultaneously detect light signals exiting the waveguides. Differences in light intensities of the received light signals at one or more wavelengths, may reveal the presence of a pathogenic germ in a liquid sample applied to the first and second measurement points.

Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.

Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.

We describe a method of selectively detecting the presence of an analyte, the method comprising: providing at least one waveguide, the waveguide having a core comprising porous material; absorbing an analyte sample into said porous material of said core such that said analyte sample is held within pores of said core; waveguiding radiation along said at least one waveguide to an output to provide output radiation; measuring one or more spectral features of said output radiation due to absorption or scattering of said waveguided radiation by said absorbed analyte sample; selectively identifying the presence of a target analyte in said analyte sample from said one or more spectral features. In embodiments spectral features are measured for multiple different waveguide core regions having different physical/chemical properties modified to provide additional selectivity to the target analyte(s), and these measurements combined to identify the target analyte.

Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.

Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.

We describe a method of selectively detecting the presence of an analyte, the method comprising: providing at least one waveguide, the waveguide having a core comprising porous material; absorbing an analyte sample into said porous material of said core such that said analyte sample is held within pores of said core; waveguiding radiation along said at least one waveguide to an output to provide output radiation; measuring one or more spectral features of said output radiation due to absorption or scattering of said waveguided radiation by said absorbed analyte sample; selectively identifying the presence of a target analyte in said analyte sample from said one or more spectral features. In embodiments spectral features are measured for multiple different waveguide core regions having different physical/chemical properties modified to provide additional selectivity to the target analyte(s), and these measurements combined to identify the target analyte.

An optical fiber includes a graphene oxide and a reduced graphene oxide and a gas sensor includes the optical fiber. A method for manufacturing the optical fiber includes coating a graphene oxide layer and reducing a part of the graphene oxide layer, and a method for manufacturing the gas sensor includes coating a graphene oxide layer and reducing a part of the graphene oxide layer.